Bioactive Materials-Mediated Regulation of Bone Marrow Microenvironment: Mechanistic Insights and Therapeutic Potentials.
Sign Up to like & getrecommendations! Published in 2025 at "Advanced materials"
DOI: 10.1002/adma.202511497
Abstract: The bone marrow microenvironment(BME) maintains bone homeostasis through multi‐cellular cooperation and signal crosstalk, its dysregulation drives pathological bone loss. In recent years, Materiobiology, a scientific discipline studying how biomaterial properties affect biological functions, has opened… read more here.
Keywords: bone; marrow microenvironment; regulation; bone marrow ... See more keywords
Intravital Imaging of Bone Marrow Microenvironment in the Mouse Calvaria and Tibia.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1425-9_15
Abstract: The complex bone marrow microenvironment or niche is an important anatomical structure responsible for hematopoiesis and providing support to the immune cells function. Being the source of immune and blood cells, the interaction of these… read more here.
Keywords: bone; marrow microenvironment; intravital imaging; bone marrow ... See more keywords
Differentially expressed proteins identified by TMT proteomics analysis in bone marrow microenvironment of osteoporotic patients
Sign Up to like & getrecommendations! Published in 2019 at "Osteoporosis International"
DOI: 10.1007/s00198-019-04884-0
Abstract: SummaryWe applied tandem mass tag (TMT)-based proteomics to investigate protein changes in bone marrow microenvironment of osteoporotic patients undergoing spine fusion. Multiple bioinformatics tools were used to identify and analyze 219 differentially expressed proteins. These… read more here.
Keywords: osteoporotic patients; microenvironment osteoporotic; marrow; marrow microenvironment ... See more keywords
Mesenchymal stem cells in the bone marrow microenvironment: a double-edged sword for AML
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DOI: 10.1007/s00432-025-06244-4
Abstract: Mesenchymal stem cells (MSCs) play a pivotal role in supporting acute myeloid leukemia (AML) cell survival, proliferation, and drug resistance through various mechanisms, including the release of soluble factors, direct cell-cell interactions, and the creation… read more here.
Keywords: bone marrow; mesenchymal stem; aml; stem cells ... See more keywords
Exosome-derived miR-let-7c promotes angiogenesis in multiple myeloma by polarizing M2 macrophages in the bone marrow microenvironment.
Sign Up to like & getrecommendations! Published in 2021 at "Leukemia research"
DOI: 10.1016/j.leukres.2021.106566
Abstract: Angiogenesis is an integral part of the multiple myeloma (MM) microenvironment, and affects tumorigenesis, progression, invasion, and metastasis. Exosomes are essential for cell-cell communication and help in regulating the bone marrow microenvironment. Herein, we investigated… read more here.
Keywords: myeloma; mir let; let; marrow microenvironment ... See more keywords
Tetrandrine overcomes drug resistance mediated by bone marrow microenvironment by regulating the expression of P-glycoprotein in acute leukemia.
Sign Up to like & getrecommendations! Published in 2022 at "Hematology"
DOI: 10.1080/16078454.2022.2034256
Abstract: Objectives: To study the effect of TET on the reversal of drug resistance in the bone marrow microenvironment, and to further promote the research on drug reversal.Methods: We established a co-culture system of bone marrow… read more here.
Keywords: bone; expression; culture; bone marrow ... See more keywords
Pathogenic Mechanisms of Systemic Mastocytosis: Unraveling the Genetic Complexity, Bone Marrow Microenvironment, and Clinical Challenges
Sign Up to like & getrecommendations! Published in 2025 at "European Journal of Haematology"
DOI: 10.1111/ejh.70004
Abstract: Systemic mastocytosis (SM) was historically classified as a myeloproliferative neoplasm, but it was redefined in 2016 as a distinct entity in the World Health Organization classification. Characterized by abnormal mast cell (MC) proliferation, SM can… read more here.
Keywords: bone marrow; genetic complexity; marrow microenvironment; systemic mastocytosis ... See more keywords
Abstract 5237: Optimizing multiple myeloma treatment approaches by elucidating tumor-stroma interactions in the bone marrow microenvironment
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Research"
DOI: 10.1158/1538-7445.am2025-5237
Abstract: Multiple Myeloma (MM) is a plasma cell malignancy arising in the bone marrow. Despite advancements in therapies, this disease becomes refractory such that relapse and death is inevitable. Immune evasion and drug resistance are partly… read more here.
Keywords: multiple myeloma; interactions bone; cell; marrow microenvironment ... See more keywords
A Novel Proteomic Profiling of the Bone Marrow Microenvironment Reveals Elevated Levels of the Chemokine CCL23 Isoforms in Acute Myeloid Leukemia
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DOI: 10.1182/blood-2019-122121
Abstract: The bone marrow (BM) microenvironment is increasingly recognized as an important contributor to acute myeloid leukemia (AML) pathogenesis. However, despite growing interest in characterizing different components and cellular architecture of the BM niche and their… read more here.
Keywords: marrow microenvironment; analysis; marrow; aml ... See more keywords
Role of CYP3A4 in bone marrow microenvironment-mediated protection of FLT3/ITD AML from tyrosine kinase inhibitors.
Sign Up to like & getrecommendations! Published in 2019 at "Blood advances"
DOI: 10.1182/bloodadvances.2018022921
Abstract: An intriguing aspect of the clinical activity of FMS-like tyrosine kinase 3 inhibitors (FLT3 TKIs) is their apparent higher activity against peripheral blasts from FLT3/internal tandem duplication (ITD) acute myeloid leukemia than marrow disease in… read more here.
Keywords: flt3; role; marrow; marrow microenvironment ... See more keywords
Cell interactions in the bone marrow microenvironment affecting myeloid malignancies.
Sign Up to like & getrecommendations! Published in 2020 at "Blood advances"
DOI: 10.1182/bloodadvances.2020002127
Abstract: The bone marrow is a complex tissue in which heterogeneous populations of stromal cells interact with hematopoietic cells to dynamically respond to organismal needs in defense, hemostasis, and oxygen delivery. Physiologic challenges modify stromal/hematopoietic cell… read more here.
Keywords: cell interactions; microenvironment affecting; interactions bone; marrow microenvironment ... See more keywords