Bone marrow niche chemoprotection of metastatic solid tumors mediated by CYP3A4
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DOI: 10.1002/cncr.34704
Abstract: The bone/bone marrow is one of the most common sites for metastatic solid tumors. Moreover, the tumor microenvironment is an essential part of cancer homeostasis. Previously, it was shown that cytochrome P450 enzymes (CYPs) are… read more here.
Keywords: bone marrow; bone; marrow niche; solid tumors ... See more keywords
The Instructive Role of the Bone Marrow Niche in Aging and Leukemia
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DOI: 10.1007/s40778-018-0143-7
Abstract: Purpose of reviewIn this review, we aim to discuss the role of the bone marrow microenvironment in supporting hematopoiesis, with particular focus on the contribution of the endothelial niche in dictating hematopoietic stem cell (HSC)… read more here.
Keywords: niche; cell; marrow niche; bone marrow ... See more keywords
Cell-specific proteome analyses of human bone marrow reveal molecular features of age-dependent functional decline
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DOI: 10.1038/s41467-018-06353-4
Abstract: Diminishing potential to replace damaged tissues is a hallmark for ageing of somatic stem cells, but the mechanisms remain elusive. Here, we present proteome-wide atlases of age-associated alterations in human haematopoietic stem and progenitor cells… read more here.
Keywords: age; analyses human; marrow niche; bone marrow ... See more keywords
Cellular immunotherapy on primary multiple myeloma expanded in a 3D bone marrow niche model
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DOI: 10.1080/2162402x.2018.1434465
Abstract: ABSTRACT Bone marrow niches support multiple myeloma, providing signals and cell-cell interactions essential for disease progression. A 3D bone marrow niche model was developed, in which supportive multipotent mesenchymal stromal cells and their osteogenic derivatives… read more here.
Keywords: marrow niche; model; myeloma; bone marrow ... See more keywords
Editorial: The Bone Marrow Niche in Normal and Malignant Haematopoiesis
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DOI: 10.3389/fcell.2022.870114
Abstract: Haematopoietic Stem Cell Biology Laboratory, Medical Research Council (MRC) Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom, MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, Medical… read more here.
Keywords: medicine; editorial bone; biology; oxford ... See more keywords