Vibrio vulnificus PlpA facilitates necrotic host cell death induced by the pore forming MARTX toxin
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DOI: 10.1007/s12275-022-1448-x
Abstract: Opportunistic pathogen Vibrio vulnificus causes severe systemic infection in humans with high mortality. Although multiple exotoxins have been characterized in V. vulnificus , their interactions and potential synergistic roles in pathogen-induced host cell death have… read more here.
Keywords: martx toxin; cell; plpa; cell death ... See more keywords
Actin Cross-Linking Effector Domain of the Vibrio vulnificus F-Type MARTX Toxin Dominates Disease Progression During Intestinal Infection
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DOI: 10.1128/iai.00627-21
Abstract: Vibrio vulnificus is an opportunistic pathogen that causes gastroenteritis and septicemia in humans. The V. vulnificus multifunctional-autoprocessing repeats-in-toxin (MARTX) toxin is a pore-forming toxin that translocates multiple functionally independent effector domains into target cells and… read more here.
Keywords: infection; toxin; vibrio vulnificus; martx toxin ... See more keywords
The Modes of Action of MARTX Toxin Effector Domains
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DOI: 10.3390/toxins10120507
Abstract: Many Gram-negative bacterial pathogens directly deliver numerous effector proteins from the bacterium to the host cell, thereby altering the target cell physiology. The already well-characterized effector delivery systems are type III, type IV, and type… read more here.
Keywords: effector domains; martx toxin; effector; toxin effector ... See more keywords