Marburg virus‐like particles produced in insect cells induce neutralizing antibodies in rhesus macaques
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DOI: 10.1002/jmv.24832
Abstract: Marburg virus (MARV), which is one of the most virulent agents in the world, causes lethal haemorrhagic fever in humans and nonhuman primates (NHPs) with a mortality rate of up to 90%. Currently, there is… read more here.
Keywords: marburg virus; marv; virus like; rhesus macaques ... See more keywords
Screening and Identification of Marburg Virus Entry Inhibitors Using Approved Drugs
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DOI: 10.1007/s12250-019-00184-3
Abstract: Marburg virus (MARV) belongs to the Filoviridae family, along with the related Ebola virus (EBOV). Although MARV is less renowned than EBOV, it causes an equally devastating disease, with clinical symptoms similar to EBOV infection… read more here.
Keywords: marburg virus; marv; approved drugs; screen ... See more keywords
A Single Amino Acid Change in the Marburg Virus Glycoprotein Arises during Serial Cell Culture Passages and Attenuates the Virus in a Macaque Model of Disease
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DOI: 10.1128/msphere.00401-17
Abstract: Marburg virus (MARV) causes disease with a high case fatality rate, and there are no approved vaccines or therapies. Serial amplification of viruses in cell culture often results in accumulation of mutations, but the effect… read more here.
Keywords: marv; cell culture; disease; virus ... See more keywords
Rousette Bat Dendritic Cells Overcome Marburg Virus-Mediated Antiviral Responses by Upregulation of Interferon-Related Genes While Downregulating Proinflammatory Disease Mediators
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DOI: 10.1128/msphere.00728-19
Abstract: Marburg viruses (MARVs) cause severe human disease resulting from aberrant immune responses. Dendritic cells (DCs) are primary targets of infection and are dysregulated by MARV. Dysregulation of DCs facilitates MARV replication and virus dissemination and… read more here.
Keywords: bat; replication; infection; virus ... See more keywords
Development of a Well-Characterized Cynomolgus Macaque Model of Marburg Virus Disease for Support of Vaccine and Therapy Development
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DOI: 10.3390/vaccines10081314
Abstract: Marburg virus (MARV) is a filovirus that can infect humans and nonhuman primates (NHPs), causing severe disease and death. Of the filoviruses, Ebola virus (EBOV) has been the primary target for vaccine and therapeutic development.… read more here.
Keywords: disease; development; marv; marburg virus ... See more keywords
Single-Shot ChAd3-MARV Vaccine in Modified Formulation Buffer Shows 100% Protection of NHPs
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DOI: 10.3390/vaccines10111935
Abstract: Marburg virus (MARV) is a virus of high human consequence with a case fatality rate of 24–88%. The global health and national security risks posed by Marburg virus disease (MVD) underscore the compelling need for… read more here.
Keywords: formulation; 100 protection; marv; chad3 marv ... See more keywords