Simultaneous identification of three pseudoallergic components in Danshen injection by using high-expression Mas-related G protein coupled receptor X2 cell membrane chromatography coupled online to HPLC-ESI-MS/MS.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of separation science"
DOI: 10.1002/jssc.201701275
Abstract: Adverse drug reactions of Danshen injection mainly manifested as pseudoallergic reactions. In the present study, salvianolic acid A and a pair of geometric isomers (isosalvianolic acid C and salvianolic acid C) were identified as pseudoallergic… read more here.
Keywords: chromatography; mas related; injection; danshen injection ... See more keywords
Pseudo-allergic compounds screened from Shengmai Injection by using high-expression Mas-related G protein-coupled receptor X2 cell membrane chromatography online coupled with liquid chromatography and mass spectrometry.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of separation science"
DOI: 10.1002/jssc.202001163
Abstract: Adverse drug reactions of Traditional Chinese medicine injection mainly manifested as pseudo-allergic reactions. In the present study, ginsenoside Rd, Ro and Rg3 were identified as pseudo-allergic components in Shengmai Injection by a high-expression Mas-related G… read more here.
Keywords: chromatography; mas related; shengmai injection; pseudo allergic ... See more keywords
Mas-related G protein-coupled receptors (Mrgprs) – Key regulators of neuroimmune interactions
Sign Up to like & getrecommendations! Published in 2021 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2021.135724
Abstract: Interplay between physiological systems in the body plays a prominent role in health and disease. At the cellular level, such interplay is orchestrated through the binding of specific ligands to their receptors expressed on cell… read more here.
Keywords: mas related; receptors mrgprs; protein coupled; coupled receptors ... See more keywords
Thieno[2,3-d]pyrimidine-Based Positive Allosteric Modulators of Human Mas-Related G Protein-Coupled Receptor X1 (MRGPRX1).
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.1c01709
Abstract: Mas-related G protein-coupled receptor X1 (MRGPRX1) is a human sensory neuron-specific receptor and potential target for the treatment of pain. Positive allosteric modulators (PAMs) of MRGPRX1 have the potential to preferentially activate the receptors at… read more here.
Keywords: mrgprx1; receptor; thieno pyrimidine; mas related ... See more keywords
Anoctamin 1/TMEM16A in pruritoceptors is essential for Mas-related G protein receptor-dependent itch.
Sign Up to like & getrecommendations! Published in 2022 at "Pain"
DOI: 10.1097/j.pain.0000000000002611
Abstract: ABSTRACT Itch is an unpleasant sensation that evokes a desire to scratch. Pathologic conditions such as allergy or atopic dermatitis produce severe itching sensation. Mas-related G protein receptors (Mrgprs) are receptors for many endogenous pruritogens.… read more here.
Keywords: related protein; drg neurons; dependent itch; itch ... See more keywords
Mas-Related G Protein-Coupled Receptors in Gastrointestinal Dysfunction and Inflammatory Bowel Disease: A Review.
Sign Up to like & getrecommendations! Published in 2023 at "British journal of pharmacology"
DOI: 10.1111/bph.16059
Abstract: Inflammatory bowel disease (IBD) is a chronic debilitating condition, hallmarked by persistent inflammation in the gastrointestinal tract. Despite recent advances in clinical treatments, the aetiology of IBD is unknown and a large proportion of patients… read more here.
Keywords: related protein; inflammatory bowel; bowel disease; coupled receptors ... See more keywords
Inhibition of Orai Channel Function Regulates Mas-Related G Protein-Coupled Receptor-Mediated Responses in Mast Cells
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.803335
Abstract: Mast cells (MCs) are tissue resident immune cells that play important roles in the pathogenesis of allergic disorders. These responses are mediated via the cross-linking of cell surface high affinity IgE receptor (FcϵRI) by antigen… read more here.
Keywords: related protein; inhibition; protein coupled; mast cells ... See more keywords