Targeting MASLD and MASH in the US Hispanic/Latino Population: A Review.
Sign Up to like & getrecommendations! Published in 2025 at "JAMA internal medicine"
DOI: 10.1001/jamainternmed.2025.4769
Abstract: Importance The prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD) in the US is highest among Hispanic/Latino individuals. Their risk of developing metabolic dysfunction-associated steatohepatitis (MASH) with fibrosis, cirrhosis with progression to hepatocellular carcinoma and… read more here.
Keywords: latino population; hispanic latino; risk; latino ... See more keywords
Chemogenomic Screening in a Patient‐Derived 3D Fatty Liver Disease Model Reveals the CHRM1‐TRPM8 Axis as a Novel Module for Targeted Intervention
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Science"
DOI: 10.1002/advs.202407572
Abstract: Metabolic dysfunction‐associated steatohepatitis (MASH) is a leading cause of chronic liver disease with few therapeutic options. To narrow the translational gap in the development of pharmacological MASH treatments, a 3D liver model from primary human… read more here.
Keywords: patient derived; model; mash; chemogenomic screening ... See more keywords
Intranuclear paraspeckle‐circular RNA TACC3 assembly forms RNA‐DNA hybrids to facilitate MASH‐related hepatocellular carcinoma growth in an m6A‐dependent manner
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Communications"
DOI: 10.1002/cac2.70061
Abstract: Metabolic dysfunction‐associated steatohepatitis (MASH) is anticipated to become the leading cause of hepatocellular carcinoma (HCC). Accumulating evidence indicates that N6‐methyladenosine (m6A)‐modified circular RNAs (circRNAs) play key roles in tumor malignant progression. However, the precise molecular… read more here.
Keywords: mash related; hepatocellular carcinoma; intranuclear paraspeckle; mash ... See more keywords
Understanding MASH: An Examination of Progression and Clinical Outcomes by Disease Severity in the TARGET-NASH Database
Sign Up to like & getrecommendations! Published in 2024 at "Advances in Therapy"
DOI: 10.1007/s12325-024-03085-4
Abstract: Metabolic dysfunction-associated steatohepatitis (MASH), the progressive form of metabolic dysfunction-associated steatotic liver disease (MASLD), is linked to cardiometabolic risk factors such as obesity and type 2 diabetes (T2D). The rising prevalence of MASH and risk… read more here.
Keywords: fibrosis; cirrhosis; progression; stage ... See more keywords
Targeting CCL24 in Inflammatory and Fibrotic Diseases: Rationale and Results from Three CM-101 Phase 1 Studies
Sign Up to like & getrecommendations! Published in 2024 at "Drug Safety"
DOI: 10.1007/s40264-024-01436-2
Abstract: Overexpression of C-C motif chemokine ligand 24 (CCL24) is associated with inflammatory and fibrotic diseases, including primary sclerosing cholangitis (PSC), systemic sclerosis, metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic dysfunction-associated steatohepatitis (MASH). CM-101 is… read more here.
Keywords: fibrotic diseases; study; mash; placebo ... See more keywords
Optimization of malting conditions for two landraces of West African sorghum and influence of mash bio-acidification on saccharification improvement
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cereal Science"
DOI: 10.1016/j.jcs.2018.12.011
Abstract: Abstract Traditional sorghum beer processing based on uncontrolled malting and mashing conditions limits significant saccharification. We optimized the amylase activity of west African sorghum to improve saccharification. Furthermore, we bio-acidified the mash with Lactobacillus plantarum… read more here.
Keywords: acidification; mash; african sorghum; saccharification ... See more keywords
Derivation of a bedside score (MASH-P) to predict 6-month mortality in tuberculous meningitis
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the Neurological Sciences"
DOI: 10.1016/j.jns.2020.116877
Abstract: BACKGROUND Tuberculous meningitis is commonly associated with a poor outcome. Simple bedside prognostic scores can help immensely in predicting the outcome. MATERIALS AND METHOD A total of 721 patients, from 5 of our previous studies,… read more here.
Keywords: bedside score; mash; model; tuberculous meningitis ... See more keywords
Optimization of Cyclophilin B-Targeted Tri-vector Inhibitors for Novel MASH Treatments
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Medicinal Chemistry"
DOI: 10.1021/acs.jmedchem.5c00301
Abstract: Cyclophilins have been implicated in the pathophysiology of metabolic dysfunction-associated steatohepatitis (MASH). Pharmacological inhibition of the cyclophilin B isoform has the potential to attenuate liver fibrosis in MASH, but current cyclophilin inhibitors in clinical trials… read more here.
Keywords: optimization cyclophilin; mash; cyclophilin; tri vector ... See more keywords
Discovery of a Novel Silybin Derivative for the Treatment of Metabolic Dysfunction-Associated Steatohepatitis.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.5c00672
Abstract: MASH has become the leading cause of liver disease worldwide, and the prevalence of MASH is steadily increasing. The development of new drugs for the treatment of MASH is urgent. Silybin has been used for… read more here.
Keywords: treatment; derivative treatment; silybin derivative; mash ... See more keywords
Discovery of the First-In-Class HSD17B13/PPAR Multitarget Modulators for the Treatment of Metabolic Dysfunction-Associated Steatohepatitis.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.5c01825
Abstract: Metabolic dysfunction-associated steatohepatitis (MASH) is a complex disease driven by multiple metabolic and inflammatory pathways. HSD17B13 is a potential therapeutic target for MASH, and PPAR regulates multiple pathological mechanisms related to MASH. Based on their… read more here.
Keywords: ppar; hsd17b13 ppar; mash; hsd17b13 ... See more keywords
Tetrahedral Framework Nucleic Acid-Based Delivery of miR-34a Inhibitor for the Treatment of Metabolic Dysfunction-Associated Steatohepatitis.
Sign Up to like & getrecommendations! Published in 2025 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.5c18832
Abstract: Metabolic dysfunction-associated steatohepatitis (MASH), a metabolic liver disorder with severe complications, features hepatic inflammation and oxidative stress. MiR-34a dysregulation is a critical contributor to MASH progression, making it a promising therapeutic target. However, clinical translation… read more here.
Keywords: 34a inhibitor; treatment; mash; mir 34a ... See more keywords