An Oxidative Dearomatization Approach to Tetrodotoxin via a Masked ortho-Benzoquinone.
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DOI: 10.1021/acs.orglett.1c03998
Abstract: Progress toward a stereoselective synthesis of tetrodotoxin (TTX) is presented. Oxidative dearomatization of a tetrasubstituted guaiacol arene yielded a masked ortho-benzoquinone that intercepted an acyl nitroso species generated in situ by the copper-catalyzed aerobic oxidation… read more here.
Keywords: masked ortho; oxidative dearomatization; ortho benzoquinone; tetrodotoxin ... See more keywords