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Published in 2023 at "Chemical communications"
DOI: 10.1039/d2cc06596g
Abstract: Thioamides, thioureas, and thiocarbamates are introduced as stable, sulfur-based metal-binding pharmacophores (MBPs) for use in metalloenzyme fragment-based drug discovery (mFBDD). MBP reactivity, bioactivity, and structural studies show that these molecules can act as ligands for…
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Keywords:
thiourea thiocarbamate;
thiol reactivity;
thioamide thiourea;
masking thiol ... See more keywords