The Opportunity of Precision Medicine for Breast Cancer With Context‐Sensitive Tumor Suppressor Maspin
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.25969
Abstract: To improve the precision of molecular diagnosis and to develop and guide targeted therapies of breast cancer, it is essential to determine the mechanisms that underlie the specific tumor phenotypes. To this end, the application… read more here.
Keywords: medicine; maspin; breast cancer; cancer ... See more keywords
Role of cytoplasmic localization of maspin in promoting cell invasion in breast cancer with aggressive phenotype
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-90887-z
Abstract: Mammary serine protease inhibitor (maspin) is a tumor suppressor gene that is downregulated during carcinogenesis and breast cancer progression. While the nuclear localization of maspin is essential for tumor suppression, we previously reported that the… read more here.
Keywords: localization maspin; maspin; breast cancer;
Prognostic role of maspin expression in melanoma: probably far from clinical use
Sign Up to like & getrecommendations! Published in 2017 at "Histopathology"
DOI: 10.1111/his.13188
Abstract: Maspin, a member of the serpin superfamily, is a double-face gene enacting different activities in cancer. Several studies support that in melanoma maspin loss could contribute to disease progression and metastatic dissemination, sustaining its putative… read more here.
Keywords: role maspin; maspin; expression melanoma; prognostic role ... See more keywords
Double immunostaining for maspin and p53 on cell blocks increases the diagnostic value of biliary brushing cytology
Sign Up to like & getrecommendations! Published in 2017 at "Pathology International"
DOI: 10.1111/pin.12505
Abstract: Our objective is to elucidate the usefulness of maspin/p53 double immunostaining on biliary brushing cytology specimens. We first examined the expression of maspin in the biliary epithelium with variable degrees of dysplasia using surgically resected… read more here.
Keywords: maspin; biliary brushing; double immunostaining; maspin p53 ... See more keywords
Editor's Note: The Paradoxical Expression of Maspin in Ovarian Carcinoma
Sign Up to like & getrecommendations! Published in 2021 at "Clinical Cancer Research"
DOI: 10.1158/1078-0432.ccr-21-2122
Abstract: Maspin is a noninhibitory member of the serpin family that is down-regulated in breast carcinoma but overexpressed in pancreatic carcinoma. There are no published data regarding the role of maspin in ovarian carcinoma, which is… read more here.
Keywords: carcinoma; maspin; cell lines; maspin ovarian ... See more keywords
Different Expression Patterns of CXCR4, CCR7, Maspin and FOXP3 in Luminal Breast Cancers and Their Sentinel Node Metastases.
Sign Up to like & getrecommendations! Published in 2017 at "Anticancer research"
DOI: 10.21873/anticanres.11303
Abstract: AIM Luminal A breast cancers (BC) represent low-risk tumors conferring better outcome than luminal B and human epidermal growth factor 2 (HER2)-positive or triple-negative tumors. One reason for the heterogeneous outcome among patients with luminal… read more here.
Keywords: maspin; luminal breast; breast cancers; expression ... See more keywords
Subcellular Localization of Maspin Correlates with Histone Deacetylase 1 Expression in Human Breast Cancer.
Sign Up to like & getrecommendations! Published in 2017 at "Anticancer research"
DOI: 10.21873/anticanres.11924
Abstract: BACKGROUND/AIM Maspin is known to be a tumor suppressor protein. Its nuclear localization and endogenous inhibition of histone deacetylase 1 (HDAC1) are considered crucial for its tumor suppressor activity. However, it remains unclear whether subcellular… read more here.
Keywords: human breast; maspin; breast cancer; expression ... See more keywords
Integrating the tumor-suppressive activity of Maspin with p53 in retuning the epithelial homeostasis: A working hypothesis and applicable prospects
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.1037794
Abstract: Epithelial malignant transformation and tumorous development were believed to be closely associated with the loss of its microenvironment integrity and homeostasis. The tumor-suppressive molecules Maspin and p53 were demonstrated to play a crucial role in… read more here.
Keywords: tumor suppressive; maspin; maspin p53; activity ... See more keywords
Minimally Invasive and Fast Diagnosis of Gastric Cancer Based on Maspin Levels in Different Biological Samples
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DOI: 10.3390/diagnostics13111857
Abstract: (1) Background: Human SERPINB5, commonly known as maspin, has diverse functions as a tumor suppressor. Maspin has a novel role in cell cycle control, and common variants were discovered to be associated with gastric cancer… read more here.
Keywords: maspin levels; fast diagnosis; maspin; gastric cancer ... See more keywords
Correlation between Maspin Levels in Different Biological Samples and Pathologic Features in Colorectal Adenocarcinomas
Sign Up to like & getrecommendations! Published in 2023 at "Life"
DOI: 10.3390/life13041060
Abstract: Maspin is an important biomarker which was proven to be correlated to many pathological features that can help the oncologists, the surgeons and also the pathologists for choosing the personalized treatment of the patients. Maspin… read more here.
Keywords: colorectal adenocarcinomas; maspin levels; maspin; concentrations related ... See more keywords