Absolute Bioavailability, Mass Balance, and Metabolic Profiling Assessment of [14 C]-Belumosudil in Healthy Men: A Phase 1, Open-Label, 2-Part Study.
Sign Up to like & getrecommendations! Published in 2022 at "Clinical pharmacology in drug development"
DOI: 10.1002/cpdd.1085
Abstract: Belumosudil is a selective Rho-associated coiled-coil containing protein kinase 2 (ROCK2) inhibitor. ROCK2 has been shown to drive proinflammatory response and fibrosis that occurs with chronic graft-versus-host disease; therefore, inhibition of ROCK2 has emerged as… read more here.
Keywords: balance metabolic; absolute bioavailability; part study; belumosudil ... See more keywords
A Phase 1 Study to Assess Mass Balance and Absolute Bioavailability of Zimlovisertib in Healthy Male Participants Using a 14C‐Microtracer Approach
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DOI: 10.1002/cpdd.1109
Abstract: Zimlovisertib (PF‐06650833) is a selective, reversible inhibitor of interleukin‐1 receptor‐associated kinase 4 (IRAK4) with anti‐inflammatory effects. This phase 1, open‐label, fixed‐sequence, two‐period, single‐dose study aimed to evaluate the mass balance and excretion rate of zimlovisertib… read more here.
Keywords: zimlovisertib healthy; zimlovisertib; bioavailability; mass balance ... See more keywords
Pharmacokinetics of the Multi‐kinase Inhibitor Pexidartinib: Mass Balance and Dose Proportionality
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DOI: 10.1002/cpdd.1186
Abstract: Pexidartinib is an oral small‐molecule tyrosine kinase inhibitor that selectively targets colony‐stimulating factor 1 receptor. Two phase 1 single‐center trials were conducted in healthy subjects to determine the absorption, distribution, metabolism, and excretion of pexidartinib… read more here.
Keywords: kinase inhibitor; pexidartinib; mass balance; dose proportionality ... See more keywords
Two Phase 1, Open‐Label, Mass Balance Studies to Determine the Pharmacokinetics of 14C‐Labeled Isavuconazonium Sulfate in Healthy Male Volunteers
Sign Up to like & getrecommendations! Published in 2018 at "Clinical Pharmacology in Drug Development"
DOI: 10.1002/cpdd.376
Abstract: Isavuconazonium sulfate is the water‐soluble prodrug of the active triazole isavuconazole. Two phase 1 studies were conducted to identify the metabolic profile and mass balance of isavuconazole and BAL8728 (inactive cleavage product). Seven subjects in… read more here.
Keywords: isavuconazonium sulfate; mass balance; mass;
An Open‐Label, Single‐Dose, Human Mass Balance Study of Amenamevir in Healthy Male Adults
Sign Up to like & getrecommendations! Published in 2018 at "Clinical Pharmacology in Drug Development"
DOI: 10.1002/cpdd.630
Abstract: Amenamevir is an inhibitor of the helicase‐primase enzyme complex developed for the treatment of varicella zoster virus. This mass balance study investigated the absorption, metabolism, and excretion of a single dose (200 mg) of 14C‐labeled… read more here.
Keywords: healthy male; mass balance; amenamevir healthy; balance study ... See more keywords
Physiologically‐Based Pharmacokinetic Models as Enablers of Precision Dosing in Drug Development: Pivotal Role of the Human Mass Balance Study
Sign Up to like & getrecommendations! Published in 2020 at "Clinical Pharmacology and Therapeutics"
DOI: 10.1002/cpt.2092
Abstract: Accelerated drug development for diseases with high unmet need demands patient focus without compromising scientific rigor. Precision dosing informed by physiologically-based pharmacokinetic (PBPK) models will enable inclusive clinical trials and narrow the gap between clinical… read more here.
Keywords: drug development; mass balance; based pharmacokinetic; precision dosing ... See more keywords
Quantifying weathering on variable rocks, an extension of geochemical mass balance: Critical zone and landscape evolution
Sign Up to like & getrecommendations! Published in 2017 at "Earth Surface Processes and Landforms"
DOI: 10.1002/esp.4212
Abstract: We present a statistical model of soil and rock weathering in deep profiles to expand the capacity to assess weathering to heterogeneous bedrock types, which are common at the Earth's surface. We developed the Weathering… read more here.
Keywords: mass balance; mass; model; geochemical mass ... See more keywords
How many measurements are required to construct an accurate sand budget in a large river? Insights from analyses of signal and noise
Sign Up to like & getrecommendations! Published in 2019 at "Earth Surface Processes and Landforms"
DOI: 10.1002/esp.4489
Abstract: Morphological change in river channels is frequently evaluated in the context of mass balance sediment budgets. In a closed sediment budget, measurements of sediment influx and efflux are coupled with measured changes in channel topography… read more here.
Keywords: sand; mass balance; sand budget; river ... See more keywords
Mass balance and metabolite profiling of 14C-guadecitabine in patients with advanced cancer
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DOI: 10.1007/s10637-019-00854-9
Abstract: Purpose The objective of this mass balance trial was to determine the excretory pathways and metabolic profile of the novel anticancer agent guadecitabine in humans after administration of a 14C-radiolabeled dose of guadecitabine. Experimental design… read more here.
Keywords: mass balance; guadecitabine; 14c guadecitabine; mass ... See more keywords
Advanced mass balance characterization and fractionation of algal biomass composition
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Applied Phycology"
DOI: 10.1007/s10811-021-02508-x
Abstract: Opportunities associated with biomass production and bioproduct isolation from algae-derived feedstocks are plentiful and promising; however, there are challenges associated with realizing these applications. One of the most important, and often overlooked, challenges is the… read more here.
Keywords: mass balance; characterization; algal biomass; mass ... See more keywords
Evidence of indoor sinks for formaldehyde through the field measurements using passive flux sampler and mass balance
Sign Up to like & getrecommendations! Published in 2019 at "Environmental Science and Pollution Research"
DOI: 10.1007/s11356-019-06057-2
Abstract: A measurement campaign was conducted in 24 student rooms where formaldehyde emissions from all the indoor surfaces were measured using a passive flux sampler (PFS) parallel to monitoring of indoor and outdoor concentrations as well… read more here.
Keywords: mass balance; passive flux; indoor sinks; flux sampler ... See more keywords