The utility of MASS‐FIX to detect and monitor monoclonal proteins in the clinic
Sign Up to like & getrecommendations! Published in 2017 at "American Journal of Hematology"
DOI: 10.1002/ajh.24772
Abstract: The detection and quantification of monoclonal‐proteins (M‐proteins) are necessary for the diagnosis and evaluation of response in plasma cell dyscrasias. Immunoglobulin enrichment‐coupled with matrix‐assisted laser desorption ionization time‐of‐flight mass‐spectrometry (MASS‐FIX) is a simple and inexpensive… read more here.
Keywords: monoclonal proteins; serum urine; mass; mass fix ... See more keywords
Utilizing Mass Spectrometry to Detect and Isotype Monoclonal Proteins in Urine: Comparison to Electrophoretic Methods.
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DOI: 10.1093/clinchem/hvad053
Abstract: BACKGROUND Matrix assisted laser desorption ionization time of flight mass spectrometry coupled to immune enrichment (MASS-FIX) as an alternative to serum immunofixation electrophoresis has demonstrated increased sensitivity in monoclonal protein (MP) detection with improved laboratory… read more here.
Keywords: mass spectrometry; mass fix; mass; ife ... See more keywords
Prognostic Implications of Serum Monoclonal Protein Positivity By Mass-Fix in Bone Marrow Minimal Residual Disease Negative (MRD-) Patients with Multiple Myeloma
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DOI: 10.1182/blood-2019-130771
Abstract: Introduction Minimal residual disease (MRD) status at day 100 following autologous stem-cell transplant (ASCT) in multiple myeloma (MM) patients is an important determinant of prognosis. Bone marrow (BM) based assays, i.e. next-generation flow cytometry (NGF)… read more here.
Keywords: research; mass fix; consultancy; research funding ... See more keywords
Real world test characteristics of mass spectrometry monoclonal protein monitoring in multiple myeloma
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DOI: 10.1182/blood-2025-2201
Abstract: Introduction Matrix assisted laser desorption ionization time of flight mass spectrometry (MALDI-TOF MS, mass fix) represents a sensitive and specific alternative to electrophoresis and immunofixation for quantifying monoclonal antibodies in patients with multiple myeloma (MM).… read more here.
Keywords: test; monoclonal protein; mass fix; mass ... See more keywords