The Fat Mass‐ and Obesity‐Associated (FTO) Gene to Obesity: Lessons from Mouse Models
Sign Up to like & getrecommendations! Published in 2018 at "Obesity"
DOI: 10.1002/oby.22301
Abstract: Genetic variants at the fat mass‐ and obesity‐associated (FTO) locus are strongly associated with obesity‐related traits by regulating neighboring genes. Nevertheless, it is possible that FTO protein is directly involved in mechanisms regulating body composition… read more here.
Keywords: mass obesity; obesity; fat mass; obesity associated ... See more keywords
Identification of nafamostat mesilate as an inhibitor of the fat mass and obesity-associated protein (FTO) demethylase activity.
Sign Up to like & getrecommendations! Published in 2019 at "Chemico-biological interactions"
DOI: 10.1016/j.cbi.2018.10.023
Abstract: Nafamostat mesilate is a serine protease inhibitor and used for the treatment of pancreatitis and cancers. The fat mass and obesity-associated protein (FTO) was identified to be a demethylase and played an important role in… read more here.
Keywords: protein; nafamostat mesilate; fat mass; mass obesity ... See more keywords
Ubiquitination Regulates the Proteasomal Degradation and Nuclear Translocation of the Fat Mass and Obesity-Associated (FTO) Protein.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2017.12.003
Abstract: Genetic polymorphisms in the fat mass and obesity-associated (FTO) gene have been strongly associated with obesity in humans. The cellular level of FTO is tightly regulated, with alterations in its expression influencing energy metabolism, food… read more here.
Keywords: mass obesity; obesity associated; obesity; fat mass ... See more keywords
Interaction of two flavonols with fat mass and obesity-associated protein investigated by fluorescence quenching and molecular docking
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2017.1388287
Abstract: The binding of two flavonols with fat mass and obesity-associated protein (FTO) was studied using fluorescence spectroscopy, Stern-Volmer kinetics, UV-Vis absorption, and molecular docking. The quenching of FTO fluorescence was determined to be static with… read more here.
Keywords: flavonols fat; mass obesity; fluorescence; interaction ... See more keywords
The multifaceted functions of the Fat mass and Obesity-associated protein (FTO) in normal and cancer cells
Sign Up to like & getrecommendations! Published in 2022 at "RNA Biology"
DOI: 10.1080/15476286.2021.2016203
Abstract: ABSTRACT The last decade has seen mRNA modification emerge as a new layer of gene expression regulation. The Fat mass and obesity-associated protein (FTO) was the first identified eraser of N6-methyladenosine (m6A) adducts, the most… read more here.
Keywords: mass obesity; cancer cells; associated protein; fat mass ... See more keywords
Cerebroprotective Role of N6-Methyladenosine Demethylase FTO (Fat Mass and Obesity-Associated Protein) After Experimental Stroke
Sign Up to like & getrecommendations! Published in 2022 at "Stroke"
DOI: 10.1161/strokeaha.122.040401
Abstract: Background: FTO (fat mass and obesity-associated protein) demethylates N6-methyladenosine (m6A), which is a critical epitranscriptomic regulator of neuronal function. We previously reported that ischemic stroke induces m6A hypermethylation with a simultaneous decrease in FTO expression… read more here.
Keywords: fat mass; associated protein; mass obesity; obesity associated ... See more keywords
Lack of association between fat mass and obesity-associated genetic variant (rs8050136) and type 2 diabetes mellitus.
Sign Up to like & getrecommendations! Published in 2022 at "Saudi medical journal"
DOI: 10.15537/smj.2022.43.2.20210822
Abstract: OBJECTIVES To study the genotype and allele frequency of the fat mass and obesity-associated (FTO) rs8050136 A>C genetic variant and investigate its association with type 2 diabetes mekkitus (T2DM) parameters. METHODS This study was carried out… read more here.
Keywords: mass obesity; variant; rs8050136; fat mass ... See more keywords
Mendelian Randomization: A Review of Methods for the Prevention, Assessment, and Discussion of Pleiotropy in Studies Using the Fat Mass and Obesity-Associated Gene as an Instrument for Adiposity
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.803238
Abstract: Pleiotropy assessment is critical for the validity of Mendelian randomization (MR) analyses, and its management remains a challenging task for researchers. This review examines how the authors of MR studies address bias due to pleiotropy… read more here.
Keywords: fat mass; mendelian randomization; mass obesity; pleiotropy ... See more keywords
Comprehensive mutations analyses of FTO (fat mass and obesity-associated gene) and their effects on FTO’s substrate binding implicated in obesity
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Nutrition"
DOI: 10.3389/fnut.2022.852944
Abstract: An excessive amount of fat deposition in the body leads to obesity which is a complex disease and poses a generic threat to human health. It increases the risk of various other diseases like diabetes,… read more here.
Keywords: fto substrate; fat mass; substrate binding; mass obesity ... See more keywords
Computational study of potential inhibitors for fat mass and obesity-associated protein from seaweed and plant compounds
Sign Up to like & getrecommendations! Published in 2022 at "PeerJ"
DOI: 10.7717/peerj.14256
Abstract: Background Over the past three decades, with substantial changes in lifestyle, the tendency to gain weight has increased, which is resulting in significant consequences affecting an individual’s well-being. The fat mass and obesity-associated (FTO) gene… read more here.
Keywords: fat mass; potential inhibitors; mass obesity; obesity ... See more keywords