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Published in 2018 at "Electrophoresis"
DOI: 10.1002/elps.201800082
Abstract: DNA sequencing, starting with Sanger's chain termination method in 1977 and evolving into the next generation sequencing (NGS) techniques of today that employ massively parallel sequencing (MPS), has become essential in application areas such as…
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Keywords:
dna;
massively parallel;
sequencing techniques;
forensics review ... See more keywords
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Published in 2018 at "ELECTROPHORESIS"
DOI: 10.1002/elps.201800243
Abstract: Inferring ancestry and physical characteristics of an unknown individual can contribute to the direction of the investigation and to clarify the event for unknown contributors, cold cases or identification of missing persons and disaster victims.…
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Keywords:
phenotype;
massively parallel;
snp panel;
panel ... See more keywords
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Published in 2022 at "Electrophoresis"
DOI: 10.1002/elps.202100143
Abstract: The recent introduction of polymerase chain reaction (PCR)‐massively parallel sequencing (MPS) technologies in forensics has changed the approach to allelic short tandem repeat (STR) typing because sequencing cloned PCR fragments enables alleles with identical molecular…
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Keywords:
chain reaction;
polymerase chain;
parallel sequencing;
massively parallel ... See more keywords
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Published in 2019 at "International Journal of Legal Medicine"
DOI: 10.1007/s00414-019-02110-4
Abstract: Biological samples, including skeletal remains exposed to environmental insults for extended periods of time, exhibit increasing levels of DNA damage and fragmentation. Human forensic identification methods typically use a combination of mitochondrial (mt) DNA sequencing…
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Keywords:
dna;
massively parallel;
parallel sequencing;
skeletal remains ... See more keywords
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Published in 2020 at "International Journal of Legal Medicine"
DOI: 10.1007/s00414-020-02327-8
Abstract: Skeletal remains encountered frequently in forensic applications are a challenging specimen, since their DNA is usually degraded due to harsh conditions, limiting the utilization of skeletal DNA. Forensic scientists have tried various methods to extract…
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Keywords:
capillary electrophoresis;
dna;
massively parallel;
skeletal ... See more keywords
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Published in 2020 at "Conservation Genetics Resources"
DOI: 10.1007/s12686-020-01146-8
Abstract: Non-invasive DNA sampling to identify and enumerate species is critical to population monitoring and for developing effective management strategies. However, individual DNA identification is often limited by degraded and low template DNA (LT-DNA) that routinely…
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Keywords:
parallel genotyping;
dna;
massively parallel;
low template ... See more keywords
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Published in 2020 at "American Journal of Human Genetics"
DOI: 10.1016/j.ajhg.2020.12.003
Abstract: Summary The lack of functional evidence for the majority of missense variants limits their clinical interpretability and poses a key barrier to the broad utility of carrier screening. In Lynch syndrome (LS), one of the…
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Keywords:
missense variants;
massively parallel;
msh2;
parallel functional ... See more keywords
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Published in 2021 at "American journal of human genetics"
DOI: 10.1016/j.ajhg.2021.07.001
Abstract: CYP2C9 encodes a cytochrome P450 enzyme responsible for metabolizing up to 15% of small molecule drugs, and CYP2C9 variants can alter the safety and efficacy of these therapeutics. In particular, the anti-coagulant warfarin is prescribed…
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Keywords:
cyp2c9;
massively parallel;
abundance massively;
enzyme ... See more keywords
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Published in 2018 at "Cell reports"
DOI: 10.1016/j.celrep.2018.02.003
Abstract: SUMMARY To understand the cellular basis of behavior, it is necessary to know the cell types that exist in the nervous system and their contributions to function. Spinal networks are essential for sensory processing and…
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Keywords:
single nucleus;
parallel single;
massively parallel;
activity ... See more keywords
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Published in 2020 at "Cell reports"
DOI: 10.1016/j.celrep.2020.108531
Abstract: SUMMARY CELF6 is a CELF-RNA-binding protein, and thus part of a protein family with roles in human disease; however, its mRNA targets in the brain are largely unknown. Using cross-linking immunoprecipitation and sequencing (CLIP-seq), we…
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Keywords:
analysis celf6;
massively parallel;
parallel functional;
clip massively ... See more keywords
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Published in 2020 at "Cell systems"
DOI: 10.1016/j.cels.2020.05.011
Abstract: In eukaryotes, transcription factors (TFs) orchestrate gene expression by binding to TF-binding sites (TFBSs) and localizing transcriptional co-regulators and RNA polymerase II to cis-regulatory elements. However, we lack a basic understanding of the relationship between…
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Keywords:
massively parallel;
amp response;
expression;
parallel reporter ... See more keywords