iTRAQ‐based proteomic and bioinformatic characterization of human mast cells upon infection by the influenza A virus strains H1N1 and H5N1
Sign Up to like & getrecommendations! Published in 2019 at "FEBS Letters"
DOI: 10.1002/1873-3468.13523
Abstract: Mast cells can support the replication of influenza A virus, although how this occurs is poorly understood. In the present study, using quantitative MS, we analyzed the proteome of human mast cells infected with different… read more here.
Keywords: mast cells; infection; human mast; influenza virus ... See more keywords
Awakening Allies for Breaking Microenvironment Barriers: NIR-II Guided Orthogonal Activation of Tumor-infiltrating Mast Cells for Efficient Nano-drug Delivery.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202300420
Abstract: Mast cells (MCs), powerful immune cells that heavily infiltrate cancer cells, play a crucial role in tumor formation. Activated MCs can release histamine and a family of proteases through degranulation effects, concurrently achieving endothelial junction… read more here.
Keywords: tumor infiltrating; activation tumor; mast cells; tumor ... See more keywords
Myeloid neoplasm with PDGFRB rearrangement, presenting as systemic mastocytosis‐chronic eosinophilic leukemia
Sign Up to like & getrecommendations! Published in 2022 at "American Journal of Hematology"
DOI: 10.1002/ajh.26505
Abstract: IMAGE 1 Peripheral blood film shows circulating mast cells. Both “normal” and “atypical” circulating mast cells were noted. Atypical features included hypogranular spindled cytoplasms and eccentric nuclei (panel A, Wright-Giemsa stain 20 magnification). Panel B… read more here.
Keywords: magnification; myeloid neoplasm; neoplasm pdgfrb; panel ... See more keywords
Isolation of Human Placental Mast Cells
Sign Up to like & getrecommendations! Published in 2018 at "Current Protocols in Cell Biology"
DOI: 10.1002/cpcb.52
Abstract: Mast cells have been identified as resident cells of human placental tissue by immunohistological procedures, suggesting that they may play a role in pregnancy. However, the study of placental mast cells requires their isolation. Here,… read more here.
Keywords: mast cells; mast; placental mast; isolation human ... See more keywords
FcγR-dependent apoptosis regulates tissue persistence of mucosal and connective tissue mast cells.
Sign Up to like & getrecommendations! Published in 2023 at "European journal of immunology"
DOI: 10.1002/eji.202250221
Abstract: RODENT MAST CELLS CAN BE DIVIDED INTO TWO MAJOR SUBTYPES: : the mucosal mast cell (MMC) and connective tissue mast cell (CTMC). A decade-old observation revealed a longer lifespan for CTMC compared with MMC. The… read more here.
Keywords: persistence; mast; mast cells; mast cell ... See more keywords
Evidence for the modulation of nociception in mice by central mast cells
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Pain"
DOI: 10.1002/ejp.1086
Abstract: Hyperalgesia that develops following nerve ligation corresponds temporally and in magnitude with the number of thalamic mast cells located contralateral to the ligature. We tested the possibility that mast cells modulate nociception centrally, similar to… read more here.
Keywords: evidence modulation; nociception mice; mast cells; mast ... See more keywords
Mast Cells Regulate Ductular Reaction and Intestinal Inflammation in Cholestasis Through Farnesoid X Receptor Signaling
Sign Up to like & getrecommendations! Published in 2021 at "Hepatology"
DOI: 10.1002/hep.32028
Abstract: Cholestasis is characterized by increased total bile acid (TBA) levels, which are regulated by farnesoid X receptor (FXR)/FGF15. Patients with primary sclerosing cholangitis (PSC) typically present with inflammatory bowel disease (IBD). Mast cells (MCs) (i)… read more here.
Keywords: mast cells; cholestasis; ductular reaction; farnesoid receptor ... See more keywords
Mast Cells: Therapeutic Targets For COVID-19 And Beyond.
Sign Up to like & getrecommendations! Published in 2021 at "IUBMB life"
DOI: 10.1002/iub.2552
Abstract: Mast cells (MCs) are innate immune cells that widely distribute throughout all tissues and express a variety of cell surface receptors. Upon activation, MCs can rapidly release a diverse array of pre-formed mediators residing within… read more here.
Keywords: targets covid; mast cells; therapeutic targets; cells therapeutic ... See more keywords
Activated mast cells in skeletal muscle can be a potential mediator for cancer‐associated cachexia
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Cachexia, Sarcopenia and Muscle"
DOI: 10.1002/jcsm.12714
Abstract: Eighty per cent of United States advanced cancer patients faces a worsened prognosis due to cancer‐associated cachexia. Inflammation is one driver of muscle atrophy in cachexia, and skeletal muscle‐resident immune cells could be a source… read more here.
Keywords: skeletal muscle; associated cachexia; muscle; mast cells ... See more keywords
Selective immunocapture reveals neoplastic human mast cells secrete distinct microvesicle‐ and exosome‐like populations of KIT‐containing extracellular vesicles
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Extracellular Vesicles"
DOI: 10.1002/jev2.12272
Abstract: Abstract Activating mutations in the receptor KIT promote the dysregulated proliferation of human mast cells (huMCs). The resulting neoplastic huMCs secrete extracellular vesicles (EVs) that can transfer oncogenic KIT among other cargo into recipient cells.… read more here.
Keywords: human mast; immunocapture; extracellular vesicles; kit ... See more keywords
A humanized mouse model to study mast cells mediated cutaneous adverse drug reactions
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.3ma1219-210rr
Abstract: Recently a G‐protein‐coupled receptor, MAS Related GPR Family Member X2 (MRGPRX2), was identified as a specific receptor on human mast cells responsible for IgE independent adverse drug reactions (ADR). Although a murine homologue, Mrgprb2, has… read more here.
Keywords: mice; mcs; human mcs; mast cells ... See more keywords