Master protocols: New directions in drug discovery
Sign Up to like & getrecommendations! Published in 2020 at "Contemporary Clinical Trials Communications"
DOI: 10.1016/j.conctc.2020.100568
Abstract: A master protocol is a unifying study construct that includes multiple subgroups and substudies, with patients having same or different diseases and that employ one or multiple drugs to treat it. Initially designed for oncology,… read more here.
Keywords: master; master protocol; trial; master protocols ... See more keywords
Four 2×2 factorial trials of smartphone CBT to reduce subthreshold depression and to prevent new depressive episodes among adults in the community–RESiLIENT trial (Resilience Enhancement with Smartphone in LIving ENvironmenTs): a master protocol
Sign Up to like & getrecommendations! Published in 2023 at "BMJ Open"
DOI: 10.1136/bmjopen-2022-067850
Abstract: Introduction The health burden due to depression is ever increasing in the world. Prevention is a key to reducing this burden. Guided internet cognitive–behavioural therapies (iCBT) appear promising but there is room for improvement because… read more here.
Keywords: smartphone cbt; master protocol; four factorial; depression ... See more keywords
IGNYTE-ESO: A master protocol to assess safety and activity of letetresgene autoleucel (lete-cel; GSK3377794) in HLA-A*02+ patients with synovial sarcoma or myxoid/round cell liposarcoma (Substudies 1 and 2).
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2021.39.15_suppl.tps11582
Abstract: • Unlike CAR-T cells that recognize cell surface proteins, T-cell receptors can recognize antigenic epitopes of intracellular proteins that are processed and presented on the surface of the cancer cell in the context of human… read more here.
Keywords: ignyte eso; cell; master protocol; hla ... See more keywords