Moving forward in clinical research with master protocols
Sign Up to like & getrecommendations! Published in 2021 at "Contemporary Clinical Trials"
DOI: 10.1016/j.cct.2021.106438
Abstract: With billions of dollars in research and development (R&D) funding continuing to be invested, the novel coronavirus disease 2019 (COVID-19) has become into a singular focus for the scientific community. However, the collective response from… read more here.
Keywords: forward clinical; research; master protocols; research master ... See more keywords
Master protocols: New directions in drug discovery
Sign Up to like & getrecommendations! Published in 2020 at "Contemporary Clinical Trials Communications"
DOI: 10.1016/j.conctc.2020.100568
Abstract: A master protocol is a unifying study construct that includes multiple subgroups and substudies, with patients having same or different diseases and that employ one or multiple drugs to treat it. Initially designed for oncology,… read more here.
Keywords: master; master protocol; trial; master protocols ... See more keywords
Definitions and statistical properties of master protocols for personalized medicine in oncology
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Biopharmaceutical Statistics"
DOI: 10.1080/10543406.2017.1372778
Abstract: ABSTRACT Within the field of cancer research, discovery of biomarkers and genetic mutations that are potentially predictive of treatment benefit is motivating a paradigm shift in how cancer clinical trials are conducted. In this review,… read more here.
Keywords: medicine; master protocols; definitions statistical; statistical properties ... See more keywords