Hsp70 – a master regulator in protein degradation
Sign Up to like & getrecommendations! Published in 2017 at "FEBS Letters"
DOI: 10.1002/1873-3468.12751
Abstract: Proteostasis, the controlled balance of protein synthesis, folding, assembly, trafficking and degradation, is a paramount necessity for cell homeostasis. Impaired proteostasis is a hallmark of ageing and of many human diseases. Molecular chaperones are essential… read more here.
Keywords: protein; degradation; hsp70 master; protein degradation ... See more keywords
ICAM‐1: A master regulator of cellular responses in inflammation, injury resolution, and tumorigenesis
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.2mr0220-549r
Abstract: ICAM‐1 is a cell surface glycoprotein and an adhesion receptor that is best known for regulating leukocyte recruitment from circulation to sites of inflammation. However, in addition to vascular endothelial cells, ICAM‐1 expression is also… read more here.
Keywords: tumorigenesis; resolution; master regulator; inflammation ... See more keywords
RANKL as the master regulator of osteoclast differentiation
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Bone and Mineral Metabolism"
DOI: 10.1007/s00774-020-01191-1
Abstract: RANKL, the essential cue for osteoclast differentiation, is the membrane-bound factor expressed by osteoclastogenesis-supporting cells such as osteoblasts and osteocytes. In vivo evidence indicates that RANKL functions as the indispensable and irreplaceable in the program… read more here.
Keywords: regulator osteoclast; osteoclast differentiation; master regulator; differentiation ... See more keywords
Identification of a Master Regulator of Differentiation in Toxoplasma
Sign Up to like & getrecommendations! Published in 2020 at "Cell"
DOI: 10.1016/j.cell.2019.12.013
Abstract: Summary Toxoplasma gondii chronically infects a quarter of the world’s population, and its recrudescence can cause life-threatening disease in immunocompromised individuals and recurrent ocular lesions in the immunocompetent. Acute-stage tachyzoites differentiate into chronic-stage bradyzoites, which… read more here.
Keywords: identification master; regulator differentiation; differentiation toxoplasma; toxoplasma ... See more keywords
HLH-30/TFEB Is a Master Regulator of Reproductive Quiescence.
Sign Up to like & getrecommendations! Published in 2020 at "Developmental cell"
DOI: 10.1016/j.devcel.2020.03.014
Abstract: All animals have evolved the ability to survive nutrient deprivation, and nutrient signaling pathways are conserved modulators of health and disease. In C. elegans, late-larval starvation provokes the adult reproductive diapause (ARD), a long-lived quiescent state… read more here.
Keywords: quiescence; regulator reproductive; reproductive quiescence; master regulator ... See more keywords
Caspase-2 as a Master Regulator of Genomic Stability.
Sign Up to like & getrecommendations! Published in 2021 at "Trends in cell biology"
DOI: 10.1016/j.tcb.2021.03.002
Abstract: Genomic instability underlies genesis and the development of various types of cancer. During tumorigenesis, cancer initiating cells assume a set of features, which allow them to survive and proliferate. Different mutations and chromosomal alterations promote… read more here.
Keywords: caspase; master regulator; genomic stability; caspase master ... See more keywords
Melatonin: A New Plant Hormone and/or a Plant Master Regulator?
Sign Up to like & getrecommendations! Published in 2019 at "Trends in plant science"
DOI: 10.1016/j.tplants.2018.10.010
Abstract: Melatonin is a pleiotropic molecule with many diverse actions in plants. It is considered primarily an antioxidant with important actions in the control of reactive oxygen and nitrogen species (ROS and RNS), among other free… read more here.
Keywords: plant; new plant; master regulator; plant hormone ... See more keywords
Regulating the Master Regulator: Controlling Ubiquitination by Thinking Outside the Active Site.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.6b01346
Abstract: The labeling of proteins with ubiquitin/ubiquitin-like (Ubl) proteins is crucial for several physiological processes and in the onset of various diseases. Recently, targeting ubiquitin protein labeling has shifted toward the use of allosteric mechanisms over… read more here.
Keywords: regulating master; active site; site; master regulator ... See more keywords
A regulatory circuit of two lncRNAs and a master regulator directs cell fate in yeast
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-03213-z
Abstract: Transcription of long noncoding RNAs (lncRNAs) regulates local gene expression in eukaryotes. Many examples of how a single lncRNA controls the expression of an adjacent or nearby protein-coding gene have been described. Here we examine… read more here.
Keywords: circuit; regulatory circuit; master regulator; transcription ... See more keywords
MRCK: a master regulator of tissue remodeling or another ‘ROCK’ in the epithelial block?
Sign Up to like & getrecommendations! Published in 2021 at "Tissue Barriers"
DOI: 10.1080/21688370.2021.1916380
Abstract: ABSTRACT The epithelium forms a smart barrier to the external environment that can remodel whilst maintaining tissue integrity, a feature important for development, homeostasis, and function. Its dysregulation can lead to diseases ranging from cancer… read more here.
Keywords: tissue remodeling; remodeling another; mrck master; tissue ... See more keywords
Cohesin: An Emerging Master Regulator at the Heart of Cardiac Development.
Sign Up to like & getrecommendations! Published in 2023 at "Molecular biology of the cell"
DOI: 10.1091/mbc.e22-12-0557
Abstract: Cohesins are ATPase complexes that play central roles in cellular processes such as chromosome division, DNA repair, and gene expression. Cohesinopathies arise from mutations in cohesin proteins, or cohesin complex regulators, and encompass a family… read more here.
Keywords: cohesin; master regulator; cohesin emerging; heart ... See more keywords