Two-pore channels as master regulators of membrane trafficking and endocytic well-being
Sign Up to like & getrecommendations! Published in 2020 at "Current Opinion in Physiology"
DOI: 10.1016/j.cophys.2020.08.002
Abstract: Two-pore channels (TPCs) are a ubiquitous class of Ca2+- and Na+-permeable ion channels expressed within the endo-lysosomal system. They have emerged as central regulators of a wide array of physiological processes intimately linked to information… read more here.
Keywords: regulators membrane; pore channels; channels master; master regulators ... See more keywords
2009 - DISRUPTING THE MASTER REGULATORS OF BLOOD EMERGENCE IN THE MOUSE EMBRYO
Sign Up to like & getrecommendations! Published in 2019 at "Experimental Hematology"
DOI: 10.1016/j.exphem.2019.06.283
Abstract: Brachyury (T) and Tal1 are well-known regulators of Mesoderm and Blood, respectively. However, their molecular role in shaping embryonic transcriptional landscapes and in driving the emergence of these lineages during gastrulation has been challenging to… read more here.
Keywords: master regulators; emergence; disrupting master; mouse ... See more keywords
Identification of putative master regulators in rheumatoid arthritis synovial fibroblasts using gene expression data and network inference
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-73147-4
Abstract: Rheumatoid arthritis (RA) is a systemic autoimmune disease that affects the synovial joints of the body. Rheumatoid arthritis fibroblast-like synoviocytes (RA FLS) are central players in the disease pathogenesis, as they are involved in the… read more here.
Keywords: master; network; master regulators; rheumatoid arthritis ... See more keywords
Master regulators in the foam cell formation; the role of phagocytosis
Sign Up to like & getrecommendations! Published in 2020 at "European Heart Journal"
DOI: 10.1093/ehjci/ehaa946.3768
Abstract: Foam cell formation caused by modified LDL is the earliest and most noticeable manifestation of atherosclerosis. The mechanisms of foam cell formation are not fully understood and can involve altered lipid uptake, impaired lipid metabolism,… read more here.
Keywords: master; accumulation; phagocytosis; ldl ... See more keywords
MicroRNAs: master regulators in host–parasitic protist interactions
Sign Up to like & getrecommendations! Published in 2022 at "Open Biology"
DOI: 10.1098/rsob.210395
Abstract: MicroRNAs (miRNAs) are a group of small non-coding RNAs present in a wide diversity of organisms. MiRNAs regulate gene expression at a post-transcriptional level through their interaction with the 3′ untranslated regions of target mRNAs,… read more here.
Keywords: regulators host; master regulators; parasitic protist; protist interactions ... See more keywords
Integrated Bioinformatics Analysis of Master Regulators in Anaplastic Thyroid Carcinoma
Sign Up to like & getrecommendations! Published in 2019 at "BioMed Research International"
DOI: 10.1155/2019/9734576
Abstract: Anaplastic thyroid carcinoma (ATC) is one of the most aggressive and rapidly lethal tumors. However, limited advances have been made to prolong the survival and to reduce the mortality over the last decades. Therefore, identifying… read more here.
Keywords: master; anaplastic thyroid; network; analysis ... See more keywords
Network analysis of master regulators associated with invasive phenotypes in multiple myeloma
Sign Up to like & getrecommendations! Published in 2025 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2025.1586870
Abstract: To elucidate the role of transcriptional regulators (TRs) associated with invasiveness in multiple myeloma (MM), we conducted a systematic network analysis to identify key master regulators (MRs) that govern MM invasiveness. We employed a consensus… read more here.
Keywords: analysis; network; master regulators; myeloma ... See more keywords
Corrigendum: C2H2 Zinc Finger Proteins: Master Regulators of Abiotic Stress Responses in Plants
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Plant Science"
DOI: 10.3389/fpls.2020.00298
Abstract: [This corrects the article DOI: 10.3389/fpls.2020.00115.]. read more here.
Keywords: zinc finger; finger proteins; corrigendum c2h2; proteins master ... See more keywords
Reverse Engineering of the Pediatric Sepsis Regulatory Network and Identification of Master Regulators
Sign Up to like & getrecommendations! Published in 2021 at "Biomedicines"
DOI: 10.3390/biomedicines9101297
Abstract: Sepsis remains a leading cause of death in ICUs all over the world, with pediatric sepsis accounting for a high percentage of mortality in pediatric ICUs. Its complexity makes it difficult to establish a consensus… read more here.
Keywords: sepsis; network; sepsis regulatory; master regulators ... See more keywords
Gene Regulatory Network Characterization of Gastric Cancer’s Histological Subtypes: Distinctive Biological and Clinically Relevant Master Regulators
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14194961
Abstract: Simple Summary The prognosis of advanced gastric cancer patients remains unfavorable. Molecular heterogeneity has proven to be a major determinant of clinical outcomes. We characterized the transcriptome of the two major subgroups by highlighting the… read more here.
Keywords: network; gene; master regulators; gastric cancer ... See more keywords
Different Master Regulators Define Proximal and Distal Gastric Cancer: Insights into Prognosis and Opportunities for Targeted Therapy
Sign Up to like & getrecommendations! Published in 2025 at "Current Oncology"
DOI: 10.3390/curroncol32080424
Abstract: Simple Summary This study shows proximal and distal gastric cancers are biologically distinct. Proximal tumors activate FOXM1 and STAT3, linked to poor survival, while distal tumors express CDX2 and GATA6. These regulators influence prognosis and… read more here.
Keywords: different master; distal gastric; regulators define; proximal distal ... See more keywords