Hydroxycoumarins and some flavonoids from Pistacia atlantica Desf. as multi-targets inhibitors for Alzheimer's disease: Molecular docking and ADMET studies.
Sign Up to like & getrecommendations! Published in 2022 at "Current computer-aided drug design"
DOI: 10.2174/1573409919666221104093218
Abstract: OBJECTIVE The present study aimed to identify new selective inhibitors for acetylcholinesterase, butyrylcholinesterase, monoacylglycerol lipase, beta-secretase, and Asparagine endopeptidase, the targets enzymes in Alzheimer's disease. METHODS The molecular docking study is achieved using Autodock Vina.… read more here.
Keywords: molecular docking; disease; alzheimer disease; tetrahydroxyflavonol rutinoside ... See more keywords
Identification of 3-Methoxycarpachromene and Masticadienonic Acid as New Target Inhibitors against Trypanothione Reductase from Leishmania Infantum Using Molecular Docking and ADMET Prediction
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DOI: 10.3390/molecules26113335
Abstract: Polyphenolic and Terpenoids are potent natural antiparasitic compounds. This study aimed to identify new drug against Leishmania parasites, leishmaniasis’s causal agent. A new in silico analysis was accomplished using molecular docking, with the Autodock vina… read more here.
Keywords: trypanothione reductase; using molecular; masticadienonic acid; methoxycarpachromene masticadienonic ... See more keywords
Immunomodulatory Properties of Masticadienonic Acid and 3α-Hydroxy Masticadienoic Acid in Dendritic Cells
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DOI: 10.3390/molecules27041451
Abstract: Dendritic cells are antigen-presenting cells, which identify and process pathogens to subsequently activate specific T lymphocytes. To regulate the immune responses, DCs have to mature by the recognition of TLR ligands, TNFα or IFNγ. These… read more here.
Keywords: hydroxy masticadienoic; mda; masticadienoic acid; acid ... See more keywords