Altered innate immune profile in blood of systemic mastocytosis patients
Sign Up to like & getrecommendations! Published in 2022 at "Clinical and Translational Allergy"
DOI: 10.1002/clt2.12167
Abstract: Abstract Background Mast cells (MC) from systemic mastocytosis (SM) patients release MC mediators that lead to an altered microenvironment with potential consequences on innate immune cells, such as monocytes and dendritic cells (DC). Here we… read more here.
Keywords: systemic mastocytosis; innate immune; blood; blood monocytes ... See more keywords
Hereditary alpha tryptasemia is a valid genetic biomarker for severe mediator-related symptoms in mastocytosis.
Sign Up to like & getrecommendations! Published in 2020 at "Blood"
DOI: 10.1182/blood.2020006157
Abstract: Mastocytosis is a hematopoietic neoplasm characterized by expansion of KIT D816V-mutated clonal mast cells in various organs and severe or even life-threatening anaphylactic reactions. Recently, hereditary α-tryptasemia (HαT) has been described as a common genetic… read more here.
Keywords: tryptase; mediator related; tryptasemia; related symptoms ... See more keywords
Neuropsychiatric, cognitive and sexual impairment in mastocytosis patients
Sign Up to like & getrecommendations! Published in 2021 at "Orphanet Journal of Rare Diseases"
DOI: 10.1186/s13023-021-01747-y
Abstract: Background Mastocytosis is a rare disease characterised by the accumulation and/or proliferation of abnormal mast cells (MCs) in one or several organs. It may present with a number of different symptoms that involve various organ… read more here.
Keywords: cognitive sexual; professional lives; impairment; sexual impairment ... See more keywords