Investigation of non-linear Mate1-mediated efflux of trimethoprim in the mouse kidney as the mechanism underlying drug-drug interactions between trimethoprim and organic cations in the kidney.
Sign Up to like & getrecommendations! Published in 2019 at "Drug metabolism and pharmacokinetics"
DOI: 10.1016/j.dmpk.2018.08.005
Abstract: The purpose of this study was to elucidate the involvement of Mate1 in the tubular secretion of trimethoprim and saturation of Mate1-mediated efflux to address the mechanisms underlying the pharmacokinetic drug interactions with trimethoprim. Trimethoprim… read more here.
Keywords: drug interactions; drug; mate1 mediated; mediated efflux ... See more keywords
Contribution of multidrug and toxin extrusion protein 1 (MATE1) to renal secretion of trimethylamine-N-oxide (TMAO)
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DOI: 10.1038/s41598-018-25139-8
Abstract: Trimethylamine-N-oxide (TMAO) gained considerable attention because of its role as a cardiovascular risk biomarker. Organic cation transporter 2 (OCT2) mediates TMAO uptake into renal proximal tubular cells. Here we investigated the potential role of multidrug… read more here.
Keywords: mdck oct2; multidrug toxin; trimethylamine oxide; oxide tmao ... See more keywords
MATE1 expression in the cochlea and its potential involvement in cisplatin cellular uptake and ototoxicity
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DOI: 10.1080/00016489.2023.2184864
Abstract: Abstract Background Cisplatin appears to enter the cochlear cells through the organic cation transporter 2 (OCT2). There is recent evidence that multidrug and toxin extrusion protein 1 (MATE1) is involved in cisplatin-induced nephrotoxicity. Its presence… read more here.
Keywords: cellular uptake; mate1; expression; cochlea ... See more keywords