Investigation of non-linear Mate1-mediated efflux of trimethoprim in the mouse kidney as the mechanism underlying drug-drug interactions between trimethoprim and organic cations in the kidney.
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DOI: 10.1016/j.dmpk.2018.08.005
Abstract: The purpose of this study was to elucidate the involvement of Mate1 in the tubular secretion of trimethoprim and saturation of Mate1-mediated efflux to address the mechanisms underlying the pharmacokinetic drug interactions with trimethoprim. Trimethoprim… read more here.
Keywords: drug interactions; drug; mate1 mediated; mediated efflux ... See more keywords