Maternal deprivation and milk replacement affect the integrity of gray and white matter in the developing lamb brain
Sign Up to like & getrecommendations! Published in 2022 at "Developmental Neurobiology"
DOI: 10.1002/dneu.22869
Abstract: The psychoendocrine evaluation of lamb development has demonstrated that maternal deprivation and milk replacement alters health, behavior, and endocrine profiles. While lambs are able to discriminate familiar and non‐familiar conspecifics (mother or lamb), only lambs… read more here.
Keywords: mother; deprivation milk; brain; milk replacement ... See more keywords
Administration of memantine reverses behavioral, histological, and electrophysiological abnormalities in rats subjected to early maternal deprivation
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Neural Transmission"
DOI: 10.1007/s00702-019-02007-x
Abstract: Schizophrenia (SCZ) is a severe and chronic neurodevelopmental disorder with onset occurring during adolescence or early adulthood; notwithstanding, the brain dysfunction occurs before the disease and is not clinically evident. Recently, memantine (MEM) had been… read more here.
Keywords: memantine reverses; maternal deprivation; early maternal; administration memantine ... See more keywords
Effects of genetic and environmental risk for schizophrenia on hippocampal activity and psychosis-like behavior in mice
Sign Up to like & getrecommendations! Published in 2018 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2017.10.039
Abstract: HIGHLIGHTSMaternal deprivation alters the basal levels of activity with the hippocampal subfields in mice.Maternal deprivation induces a state of spontaneous hyperactivity and impairs prepulse inhibition.Expression of a dominant negative form of Disc1 impairs cued and… read more here.
Keywords: maternal deprivation; pathology; disc1; activity ... See more keywords
Combined early life stressors: Prenatal nicotine and maternal deprivation interact to influence affective and drug seeking behavioral phenotypes in rats
Sign Up to like & getrecommendations! Published in 2019 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2018.07.022
Abstract: Abstract Early life stress (ELS) increases the risk for later cognitive and emotional dysfunction, and has been implicated in the etiology of multiple psychiatric disorders. We hypothesize that combined insults during gestation and infancy, critical… read more here.
Keywords: maternal deprivation; prenatal nicotine; early life; pne ... See more keywords
Maternal deprivation impairs memory and cognitive flexibility, effect that is avoided by environmental enrichment
Sign Up to like & getrecommendations! Published in 2020 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2020.112468
Abstract: Maternal deprivation (MD) causes cognitive deficits that persist until adulthood. Thereby, the environmental enrichment (EE) is widely used to increase brain plasticity. Here, pregnant female rats were used and their offspring were submitted to neonatal… read more here.
Keywords: maternal deprivation; cognitive flexibility; environmental enrichment; memory cognitive ... See more keywords
Targeting histone deacetylation for recovery of maternal deprivation-induced changes in BDNF and AKAP150 expression in the VTA
Sign Up to like & getrecommendations! Published in 2018 at "Experimental Neurology"
DOI: 10.1016/j.expneurol.2018.08.002
Abstract: &NA; Severe early life stressors increase the probability of developing psychiatric disorders later in life through modifications in neuronal circuits controlling brain monoaminergic signaling. Our previous work demonstrated that 24 h maternal deprivation (MD) in… read more here.
Keywords: vta; maternal deprivation; levels vta; synaptic levels ... See more keywords
Dual influences of early-life maternal deprivation on histone deacetylase activity and recognition memory in rats
Sign Up to like & getrecommendations! Published in 2017 at "Neuroscience"
DOI: 10.1016/j.neuroscience.2016.12.054
Abstract: Exposure to stress early in life may negatively impact nervous system functioning, including increasing the proneness to learning and memory impairments later in life. Maternal deprivation, a model of early-life stress, hinders memory in adult… read more here.
Keywords: recognition memory; maternal deprivation; life; memory ... See more keywords
Early maternal deprivation impairs learning and memory and alters hippocampal gene expression in adult male rats
Sign Up to like & getrecommendations! Published in 2021 at "Neurobiology of Learning and Memory"
DOI: 10.1016/j.nlm.2021.107479
Abstract: Maternal deprivation (MD) in early life severely disrupts hippocampal development, leading to persistent cognitive and behavior deficits. The current study uncovered that early MD (P1-P21) impaired spatial learning and memory capacity detected by Morris water… read more here.
Keywords: maternal deprivation; adult; male rats; learning memory ... See more keywords
Sensitization of P2X3 receptors in insular cortex contributes to visceral pain of adult rats with neonatal maternal deprivation
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Pain"
DOI: 10.1177/1744806918764731
Abstract: Aims Insular cortex is a brain region critical for processing of the sensation. Purinergic receptors are involved in the formation of chronic pain. The aim of the present study was to explore the role and… read more here.
Keywords: maternal deprivation; insular cortex; pain; neonatal maternal ... See more keywords
Downregulation of GRK6 in arcuate nucleus promotes chronic visceral hypersensitivity via NF-κB upregulation in adult rats with neonatal maternal deprivation
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Pain"
DOI: 10.1177/1744806920930858
Abstract: Aims The arcuate nucleus is a vital brain region for coursing of pain command. G protein-coupled kinase 6 (GRK6) accommodates signaling through G protein-coupled receptors. Studies have demonstrated that GRK6 is involved in inflammatory pain… read more here.
Keywords: maternal deprivation; arcuate nucleus; grk6; neonatal maternal ... See more keywords