Crystal structure of Maternal Embryonic Leucine Zipper Kinase (MELK) in complex with dorsomorphin (Compound C).
Sign Up to like & getrecommendations! Published in 2019 at "Archives of biochemistry and biophysics"
DOI: 10.1016/j.abb.2019.05.014
Abstract: Maternal Embryonic Leucine Zipper Kinase (MELK) is overexpressed in various tumors which has been convincingly linked to tumor cell survival. As such, MELK became an interesting target for pharmacological intervention. In this study we present… read more here.
Keywords: maternal embryonic; leucine zipper; melk; embryonic leucine ... See more keywords
Maternal and embryonic trace element concentrations and stable isotope fractionation in the smalleye smooth-hound (Mustelus higmani).
Sign Up to like & getrecommendations! Published in 2020 at "Chemosphere"
DOI: 10.1016/j.chemosphere.2020.127183
Abstract: Here, we evaluate maternal offloading of 16 trace elements (Essential: Co, Cr, Cu, Fe, Mn, Ni, Se and Zn; Nonessential: Al, As, Ba, Cd, Hg, Pb, Tl and U) and determine mother-offspring isotopic fractionation of… read more here.
Keywords: maternal embryonic; trace; muscle; fractionation ... See more keywords
Maternal Embryonic Leucine Zipper Kinase (MELK), a Potential Therapeutic Target for Neuroblastoma
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DOI: 10.1158/1535-7163.mct-18-0819
Abstract: Maternal embryonic leucine zipper kinase (MELK) activates pathways that mediate aggressive tumor growth and therapy resistance in many types of adult cancers. Pharmacologic and genomic inhibition of MELK impairs tumor growth and increases sensitivity to… read more here.
Keywords: leucine zipper; zipper kinase; target; maternal embryonic ... See more keywords
Maternal embryonic leucine zipper kinase is a novel target for proliferation-associated high-risk myeloma
Sign Up to like & getrecommendations! Published in 2017 at "Haematologica"
DOI: 10.3324/haematol.2017.172973
Abstract: Treatment of high-risk patients is a major challenge in multiple myeloma. This is especially true for patients assigned to the gene expression profiling-defined proliferation subgroup. Although recent efforts have identified some key players of proliferative… read more here.
Keywords: maternal embryonic; myeloma; melk; high risk ... See more keywords