Maternal immune activation alters adult behavior, intestinal integrity, gut microbiota and the gut inflammation
Sign Up to like & getrecommendations! Published in 2021 at "Brain and Behavior"
DOI: 10.1002/brb3.2133
Abstract: Schizophrenia is characterized by several core behavioral features, in which the gastrointestinal symptoms are frequently reported. Maternal immune activation (MIA) has been developed in a rodent model to study neurodevelopmental disorders such as schizophrenia. However,… read more here.
Keywords: immune activation; maternal immune; gut; alters adult ... See more keywords
Granulocyte colony‐stimulating factor has a sex‐dependent positive effect in the maternal immune activation‐induced autism model
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Developmental Neuroscience"
DOI: 10.1002/jdn.10221
Abstract: The medical intervention for autism spectrum disorder (ASD) is restricted to ameliorating comorbid situations. Granulocyte colony‐stimulating factor (G‐CSF) is a growth factor that enhances the proliferation, differentiation, and survival of hematopoietic progenitor cells. In the… read more here.
Keywords: granulocyte colony; autism; maternal immune; factor ... See more keywords
The instrumental role of operant paradigms in translational psychiatric research: Insights from a maternal immune activation model of schizophrenia risk
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the Experimental Analysis of Behavior"
DOI: 10.1002/jeab.753
Abstract: Rigorous behavioral analysis is essential to the translation of research conducted using animal models of neuropsychiatric disease. Here we discuss the use of operant paradigms within our lab as a powerful approach for exploring the… read more here.
Keywords: operant paradigms; model schizophrenia; maternal immune; research ... See more keywords
Context is key: Maternal immune responses to pig allogeneic embryos
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Reproduction and Development"
DOI: 10.1002/mrd.23624
Abstract: Successful establishment of pregnancy includes the achievement of a state of immune tolerance toward the embryos (and placenta), where the well‐coordinated maternal immune system is capable of recognizing conceptus antigens while maintaining maternal defense against… read more here.
Keywords: pig allogeneic; immune responses; allogeneic embryos; maternal immune ... See more keywords
Prenatal Stress, Maternal Immune Dysregulation, and Their Association With Autism Spectrum Disorders
Sign Up to like & getrecommendations! Published in 2018 at "Current Psychiatry Reports"
DOI: 10.1007/s11920-018-0945-4
Abstract: Purpose of ReviewWhile genetic factors are a major etiological contributor to autism spectrum disorder (ASD), evidence also supports a role for environmental factors. Herein, we will discuss two such factors that have been associated with… read more here.
Keywords: prenatal stress; maternal immune; immune dysregulation; autism spectrum ... See more keywords
Altered maternal immune networks are associated with adverse child neurodevelopment: Impact of alcohol consumption during pregnancy
Sign Up to like & getrecommendations! Published in 2018 at "Brain, Behavior, and Immunity"
DOI: 10.1016/j.bbi.2018.05.004
Abstract: Cytokines and chemokines are potent modulators of brain development and as such, dysregulation of the maternal immune system can result in deviations in the fetal cytokine balance, altering the course of typical brain development, and… read more here.
Keywords: maternal immune; child; alcohol; neurodevelopmental delay ... See more keywords
Environmental influences on placental programming and offspring outcomes following maternal immune activation
Sign Up to like & getrecommendations! Published in 2020 at "Brain, Behavior, and Immunity"
DOI: 10.1016/j.bbi.2019.08.192
Abstract: Adverse experiences during pregnancy induce placental programming, affecting the fetus and its developmental trajectory. However, the influence of 'positive' maternal experiences on the placenta and fetus remain unclear. In animal models of early life stress,… read more here.
Keywords: immune activation; maternal immune; mia; placental programming ... See more keywords
Maternal immune activation alters visual acuity and retinogeniculate axon pruning in offspring mice
Sign Up to like & getrecommendations! Published in 2020 at "Brain, Behavior, and Immunity"
DOI: 10.1016/j.bbi.2020.08.017
Abstract: Individuals with autism spectrum disorder (ASD) have been found to have a variety of sensory processing deficits. Here we report that maternal immune activation, a known factor for ASD, impairs visual acuity in the offspring… read more here.
Keywords: immune activation; maternal immune; acuity; offspring mice ... See more keywords
Peripubertal stress following maternal immune activation sex-dependently alters depression-like behaviors in offspring
Sign Up to like & getrecommendations! Published in 2020 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2020.112800
Abstract: There is an increasing evidence that maternal immune activation can render the offspring more vulnerable to the impacts of peripubertal stress on behavioral abnormalities in adulthood. The aim of this study was to investigate the… read more here.
Keywords: depression; immune activation; maternal immune; peripubertal stress ... See more keywords
Mitogen-activated protein kinase (MAPK) signalling corresponds with distinct behavioural profiles in a rat model of maternal immune activation
Sign Up to like & getrecommendations! Published in 2021 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2020.112876
Abstract: Dysfunction within the mitogen-activated protein kinase (MAPK) cascade has been recognised as a pathological feature of schizophrenia, however the possible mechanistic connection to the disease phenotype remains unexplored. Using the maternal immune activation (MIA) rat… read more here.
Keywords: maternal immune; protein kinase; activated protein; kinase mapk ... See more keywords
Hyperactivation of the amygdala correlates with impaired social play behavior of prepubertal male rats in a maternal immune activation model
Sign Up to like & getrecommendations! Published in 2021 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2021.113503
Abstract: Maternal infection during pregnancy is an environmental risk factor for neurodevelopmental dysfunction, such as autism spectrum disorder (ASD). This study investigated the effect of maternal immune activation (MIA) on the behavior profile of prepubertal offspring… read more here.
Keywords: social play; maternal immune; hyperactivation; play behavior ... See more keywords