Maternal separation affects expression of stress response genes and increases vulnerability to ethanol consumption
Sign Up to like & getrecommendations! Published in 2018 at "Brain and Behavior"
DOI: 10.1002/brb3.841
Abstract: Maternal separation is an early life stress event associated with behavioral alterations and ethanol consumption. We aimed to expand the current understanding on the molecular mechanisms mediating the impact of postnatal stress on ethanol consumption. read more here.
Keywords: ethanol consumption; stress; maternal separation;
Maternal separation: Does it hold the potential to model consequences of postpartum depression?
Sign Up to like & getrecommendations! Published in 2022 at "Developmental psychobiology"
DOI: 10.1002/dev.22219
Abstract: The postpartum period is a sensitive time where women are especially vulnerable to develop postpartum depression (PPD), with 10%-15% of women affected. This review investigates whether the maternal separation (MS) paradigm in rodents holds the… read more here.
Keywords: postpartum depression; maternal separation; separation hold; model ... See more keywords
One week of maternal separation induces more frequent, but less predictable, maternal caregiving behaviors
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Developmental Neuroscience"
DOI: 10.1002/jdn.10230
Abstract: Rodent models of early life adversity disrupt typical interactions between dams and offspring, impacting pup development over the lifespan. Predictability of caregiver interactions is a critical feature of the environment, and unpredictability is associated with… read more here.
Keywords: less predictable; maternal separation; care; week maternal ... See more keywords
Maternal Separation Model of Postpartum Depression: Potential Role for Nucleus Accumbens Dopamine D1-D2 Receptor Heteromer.
Sign Up to like & getrecommendations! Published in 2020 at "Neurochemical research"
DOI: 10.1007/s11064-020-03145-5
Abstract: Postpartum depression is a mood disorder with a distinct neurobiological and behavioural profile occurring during and after the postpartum period. Dopamine pathways in the limbic regions of the brain such as the nucleus accumbens (NAc)… read more here.
Keywords: separation model; depression; postpartum depression; maternal separation ... See more keywords
Maternal separation exacerbates Alzheimer’s disease-like behavioral and pathological changes in adult APPswe/PS1dE9 mice
Sign Up to like & getrecommendations! Published in 2017 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2016.10.030
Abstract: &NA; Alzheimer's disease (AD), the most common neurodegenerative disorder that gradually destroys memory and cognitive abilities in the elderly, makes a huge emotional and economic burden on the patients and their families. The presence of… read more here.
Keywords: ps1de9 mice; appswe ps1de9; maternal separation;
Early-life stress, microbiota, and brain development: probiotics reverse the effects of maternal separation on neural circuits underpinning fear expression and extinction in infant rats
Sign Up to like & getrecommendations! Published in 2019 at "Developmental Cognitive Neuroscience"
DOI: 10.1016/j.dcn.2019.100627
Abstract: Early-life stress has pervasive, typically detrimental, effects on physical and mental health across the lifespan. In rats, maternal-separation stress results in premature expression of an adult-like profile of fear regulation that predisposes stressed rats to… read more here.
Keywords: life stress; early life; probiotic treatment; stress ... See more keywords
AMBMP activates WNT pathway and alleviates stress-induced behaviors in maternal separation and chronic stress models.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2020.173192
Abstract: Depressive disorders are both prevalent and debilitating, and a proportion of patients have treatment resistance to classic antidepressants. Recent evidence has implicated the intracellular WNT signaling pathway as having a key role in the pathogenesis… read more here.
Keywords: chronic stress; separation chronic; stress; maternal separation ... See more keywords
The effects of maternal separation stress experienced by parents on male reproductive potential in the next generation
Sign Up to like & getrecommendations! Published in 2020 at "Heliyon"
DOI: 10.1016/j.heliyon.2020.e04807
Abstract: There is little information available about the effects of early-life parental stress on the reproductive potential of the next generation. The aim of this study is to examine the reproductive potential of male mice whose… read more here.
Keywords: reproductive potential; generation; stress; experienced parents ... See more keywords
Neonatal maternal separation leads to a dampening of inflammation-related mechanical and thermal hypersensitivity in juvenile rats
Sign Up to like & getrecommendations! Published in 2018 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2018.03.044
Abstract: Early life stress (ELS) constitutes a risk factor for the later development of psychopathological disorders partly displaying pain comorbidity. Since ELS may hence be expected to have an impact on pain processing the present study… read more here.
Keywords: mechanical thermal; inflammation; neonatal maternal; maternal separation ... See more keywords
An Omega-3-rich Anti-inflammatory Diet Improved Widespread Allodynia and Worsened Metabolic Outcomes in Adult Mice Exposed to Neonatal Maternal Separation
Sign Up to like & getrecommendations! Published in 2021 at "Neuroscience"
DOI: 10.1016/j.neuroscience.2021.06.001
Abstract: Inflammation plays a key role in the progression and maintenance of chronic pain, which impacts the lives of millions of Americans. Despite growing evidence that chronic pain can be improved by treating underlying inflammation, successful… read more here.
Keywords: anti inflammatory; pain like; maternal separation; neonatal maternal ... See more keywords
Systematic review and meta-analysis: effects of maternal separation on anxiety-like behavior in rodents
Sign Up to like & getrecommendations! Published in 2020 at "Translational Psychiatry"
DOI: 10.1038/s41398-020-0856-0
Abstract: The mechanisms by which childhood maltreatment increases anxiety is unclear, but a propensity for increased defensive behavior in rodent models of early life stress (ELS) suggests that work in rodents may clarify important mechanistic details… read more here.
Keywords: review meta; behavior rodents; systematic review; defensive behavior ... See more keywords