The maternal‐zygotic transition and zygotic activation of the Mnemiopsis leidyi genome occurs within the first three cleavage cycles
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Reproduction and Development"
DOI: 10.1002/mrd.22926
Abstract: The maternal‐zygotic transition (MZT) describes the developmental reprogramming of gene expression marked by the degradation of maternally supplied gene products and activation of the zygotic genome. While the timing and duration of the MZT vary… read more here.
Keywords: eight cell; maternal zygotic; zygotic transition; cell stage ... See more keywords
Five multicopy gene family genes expressed during the maternal-to-zygotic transition are not essential for mouse development.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.11.004
Abstract: Upon fertilization, oocytes transform into totipotent and pluripotent cleavage stage cells through the maternal-to-zygotic transition (MZT), which is regulated by maternal factors and zygotic genome activation (ZGA). Here, we investigated the in vivo function of 16… read more here.
Keywords: gene family; five multicopy; multicopy gene; maternal zygotic ... See more keywords
Precise Temporal Regulation of Post-transcriptional Repressors Is Required for an Orderly Drosophila Maternal-to-Zygotic Transition
Sign Up to like & getrecommendations! Published in 2020 at "Cell reports"
DOI: 10.1016/j.celrep.2020.107783
Abstract: SUMMARY In animal embryos, the maternal-to-zygotic transition (MZT) hands developmental control from maternal to zygotic gene products. We show that the maternal proteome represents more than half of the protein-coding capacity of Drosophila melanogaster’s genome,… read more here.
Keywords: transcriptional repressors; post transcriptional; maternal zygotic; zygotic transition ... See more keywords
Comparative transcriptome analysis explores maternal to zygotic transition during Eriocheir sinensis early embryogenesis.
Sign Up to like & getrecommendations! Published in 2019 at "Gene"
DOI: 10.1016/j.gene.2018.10.036
Abstract: The maternal genome directs almost all aspects of early animal development. As development proceeds, the elimination of maternal gene products and zygotic genome activation (ZGA) occur during the maternal to zygotic transition (MZT). To study… read more here.
Keywords: sinensis; early embryogenesis; maternal zygotic; zygotic transition ... See more keywords
Maternal-to-zygotic transition as a potential target for niclosamide during early embryogenesis.
Sign Up to like & getrecommendations! Published in 2019 at "Toxicology and applied pharmacology"
DOI: 10.1016/j.taap.2019.114699
Abstract: Niclosamide is an antihelminthic drug used worldwide for the treatment of tapeworm infections. Recent drug repurposing screens have highlighted the broad bioactivity of niclosamide across diverse mechanisms of action. As a result, niclosamide is being… read more here.
Keywords: target niclosamide; embryogenesis; maternal zygotic; zygotic transition ... See more keywords
KDM4A regulates the maternal-to-zygotic transition by protecting broad H3K4me3 domains from H3K9me3 invasion in oocytes
Sign Up to like & getrecommendations! Published in 2020 at "Nature cell biology"
DOI: 10.1038/s41556-020-0494-z
Abstract: The importance of germline-inherited post-translational histone modifications on priming early mammalian development is just emerging 1 – 4 . Histone H3 lysine 9 (H3K9) trimethylation is associated with heterochromatin and gene repression during cell-fate change… read more here.
Keywords: broad h3k4me3; maternal zygotic; zygotic transition; kdm4a ... See more keywords
Dynamics of the epigenetic landscape during the maternal-to-zygotic transition
Sign Up to like & getrecommendations! Published in 2018 at "Nature Reviews Molecular Cell Biology"
DOI: 10.1038/s41580-018-0008-z
Abstract: A remarkable epigenetic remodelling process occurs shortly after fertilization, which restores totipotency to the zygote. This involves global DNA demethylation, chromatin remodelling, genome spatial reorganization and substantial transcriptional changes. Key to these changes is the… read more here.
Keywords: transition; chromatin; maternal zygotic; landscape ... See more keywords
102 A delay in maternal zygotic transition may lead to early embryonic loss in poor-quality bovine blastocysts
Sign Up to like & getrecommendations! Published in 2020 at "Reproduction, Fertility and Development"
DOI: 10.1071/rdv32n2ab102
Abstract: Increased genetic potential and performance of dairy cows has coincided with a decline in fertility. Early embryonic mortality accounts for 75-80% of this decline in fertility, costing the industry over $1.28 trillion worldwide. Despite advancements… read more here.
Keywords: quality; poor quality; embryo mortality; maternal zygotic ... See more keywords
Structure-function analysis of Cdc25Twine degradation at the Drosophila maternal-to-zygotic transition
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DOI: 10.1080/19336934.2022.2043095
Abstract: ABSTRACT Downregulation of protein phosphatase Cdc25Twine activity is linked to remodelling of the cell cycle during the Drosophila maternal-to-zygotic transition (MZT). Here, we present a structure-function analysis of Cdc25Twine. We use chimeras to show that… read more here.
Keywords: drosophila maternal; structure function; cdc25twine; zygotic transition ... See more keywords
Notch Signalling Under Maternal-to-Zygotic Transition
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DOI: 10.1080/19336934.2022.2139981
Abstract: ABSTRACT The development of all animal embryos is initially directed by the gene products supplied by their mothers. With the progression of embryogenesis, the embryo's genome is activated to command subsequent developments. This transition, which… read more here.
Keywords: notch signaling; zygotic transition; notch signalling; maternal zygotic ... See more keywords
Developmental series of gene expression clarifies maternal mRNA provisioning and maternal-to-zygotic transition in a reef-building coral
Sign Up to like & getrecommendations! Published in 2021 at "BMC Genomics"
DOI: 10.1186/s12864-021-08114-y
Abstract: Background Maternal mRNA provisioning of oocytes regulates early embryogenesis. Maternal transcripts are degraded as zygotic genome activation (ZGA) intensifies, a phenomenon known as the maternal-to-zygotic transition (MZT). Here, we examine gene expression over nine developmental… read more here.
Keywords: maternal zygotic; maternal mrna; zygotic transition; mrna provisioning ... See more keywords