Semi-synthesis and characterization of some new matrine derivatives as insecticidal agents.
Sign Up to like & getrecommendations! Published in 2020 at "Pest management science"
DOI: 10.1002/ps.5817
Abstract: BACKGROUND Matrine is an important traditional plant-derived insecticide with broad-spectrum activity. However, due to its moderate activity, matrine is mainly applied in combination with other pesticides. In order to discover new potential natural-product-based crop protection… read more here.
Keywords: insecticidal activity; matrine; matrine derivatives; insecticidal activities ... See more keywords
Matrine can be absorbed and transmitted bidirectionally to defend aphids (Hemiptera: Aphididae) on wheat and pepper.
Sign Up to like & getrecommendations! Published in 2023 at "Pest management science"
DOI: 10.1002/ps.7376
Abstract: BACKGROUND Although matrine is widely used, the knowledge of its absorption and transport mechanisms in crops remains unexplored. In this study, three methods including foliar application, hydroponics, and seed immersion were used to investigate whether… read more here.
Keywords: wheat; transmitted bidirectionally; matrine absorbed; matrine ... See more keywords
Matrine promotes liver cancer cell apoptosis by inhibiting mitophagy and PINK1/Parkin pathways
Sign Up to like & getrecommendations! Published in 2018 at "Cell Stress and Chaperones"
DOI: 10.1007/s12192-018-0937-7
Abstract: Matrine is a natural alkaloid isolated from the root and stem of the legume plant Sophora. Its anti-proliferative and pro-apoptotic effects on several types of cancer have been well-documented. However, the role of matrine in… read more here.
Keywords: parkin pathways; matrine; pink1 parkin; cell ... See more keywords
Study on mechanism of matrine in treatment of COVID-19 combined with liver injury by network pharmacology and molecular docking technology.
Sign Up to like & getrecommendations! Published in 2021 at "Drug delivery"
DOI: 10.1080/10717544.2021.1879313
Abstract: The aim of the present study was to investigate the pharmacological mechanism of matrine in treatment of COVID-19 combined with liver injury. Potential targets related to matrine, COVID-19 and liver injury were identified from several… read more here.
Keywords: matrine; pharmacology; liver injury; injury ... See more keywords
Potential mechanism underlying the effect of matrine on COVID-19 patients revealed through network pharmacological approaches and molecular docking analysis
Sign Up to like & getrecommendations! Published in 2020 at "Archives of Physiology and Biochemistry"
DOI: 10.1080/13813455.2020.1817944
Abstract: Abstract Background The clinical efficacy of matrine in treating coronavirus disease (COVID-19) has been confirmed; however, its underlying mechanism of action remains unknown. Methods TCMSP, SwissTargetPrediction, SEA, GeneCards, CTD, and TTD were used to identify… read more here.
Keywords: network; mechanism; analysis; matrine ... See more keywords
Matrine protects colon mucosal epithelial cells against inflammation and apoptosis via the Janus kinase 2 /signal transducer and activator of transcription 3 pathway
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2022.2031676
Abstract: ABSTRACT Ulcerative colitis (UC) is a type of chronic disease of inflammation, and matrine has anti-inflammatory activity. However, it is unclear that whether matrine can alleviate UC. This study aimed to evaluate the effect of… read more here.
Keywords: cell viability; matrine; apoptosis; stat3 ... See more keywords
Matrine Combined with Mammalian Target of Rapamycin Inhibitor Enhances Anti-Tumor Efficacy of dendritic cell Vaccines in hepatocellular carcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2022.2037855
Abstract: ABSTRACT Dendritic cells (DCs), as the most important antigen-presenting cells, play a crucial role in T cell activation. The latest research showed that inhibition of the mammalian target of rapamycin (mTOR) could enhance DCs maturation,… read more here.
Keywords: cell; matrine; lps ku0063794; inhibitor ... See more keywords
Matrine impedes colorectal cancer proliferation and migration by downregulating endoplasmic reticulum lipid raft associated protein 1 expression.
Sign Up to like & getrecommendations! Published in 2022 at "Bioengineered"
DOI: 10.1080/21655979.2022.2060777
Abstract: Matrine exhibits anti-tumor effect on the proliferation and invasion of colorectal cancer (CRC) cells by reducing the activity of the p38 signaling pathway. However, these studies were limited because the underlying mechanism by which matrine… read more here.
Keywords: colorectal cancer; matrine; proliferation migration; crc ... See more keywords
Proteus, Matrine, and Pyridalyl Toxicity and Their Sublethal Effects on Orius laevigatus (Hemiptera: Anthocoridae)
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Economic Entomology"
DOI: 10.1093/jee/toab267
Abstract: Abstract Proteus, matrine, and pyridalyl were tested in the laboratory for their effects upon Orius laevigatus (Fieber), which is a polyphagous predator used for IPM programs of Frankliniella occidentalis (Pergande). Against female adults, the most… read more here.
Keywords: matrine; proteus matrine; orius laevigatus; proteus ... See more keywords
Matrine induces Akt/mTOR signalling inhibitionâmediated autophagy and apoptosis in acute myeloid leukaemia cells
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.13049
Abstract: Pharmacological modulation of autophagy has been referred to as a promising therapeutic strategy for cancer. Matrine, a main alkaloid extracted from Sophora flavescens Ait, has antitumour activity against acute myelocytic leukaemia (AML). Whether autophagy is… read more here.
Keywords: apoptosis; matrine; autophagy; leukaemia ... See more keywords
Molecular Mechanism of Matrine from Sophora alopecuroides in the Reversing Effect of Multi-Anticancer Drug Resistance in K562/ADR Cells
Sign Up to like & getrecommendations! Published in 2019 at "BioMed Research International"
DOI: 10.1155/2019/1269532
Abstract: Multidrug resistance is the main obstacle to current chemotherapies. In this study, we evaluated the reversing effect of matrine, the principal alkaloid derived from Sophora alopecuroides, on chemoresistant leukemia K562/ADR cells. Matrine in a range… read more here.
Keywords: k562 adr; matrine; drug; effect ... See more keywords