Overexpression of Matriptase‐1 Inhibitor HAI‐1 as an Effective Strategy to Reduce Proteolytic Clipping in Chinese Hamster Ovary Cells
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DOI: 10.1002/biot.70141
Abstract: Proteolytic degradation of recombinant proteins in Chinese hamster ovary (CHO) cells remains a major challenge in biopharmaceutical manufacturing, often reducing product yield and quality. Matriptase‐1, a type II transmembrane serine protease, has been identified as… read more here.
Keywords: hai; hamster ovary; matriptase; overexpression ... See more keywords
Mild acidity likely accelerates the physiological matriptase autoactivation process: a comparative study between spontaneous and acid-induced matriptase zymogen activation
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DOI: 10.1007/s13577-020-00410-1
Abstract: The pathophysiological functions of matriptase, a type 2 transmembrane serine protease, rely primarily on its enzymatic activity, which is under tight control through multiple mechanisms. Among those regulatory mechanisms, the control of zymogen activation is… read more here.
Keywords: acid induced; zymogen activation; matriptase; activation ... See more keywords
Matriptase-2 deficiency protects from obesity by modulating iron homeostasis
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DOI: 10.1038/s41467-018-03853-1
Abstract: Alterations in iron status have frequently been associated with obesity and other metabolic disorders. The hormone hepcidin stands out as a key regulator in the maintenance of iron homeostasis by controlling the main iron exporter,… read more here.
Keywords: iron homeostasis; obesity; matriptase; iron ... See more keywords
The Kunitz Domain I of Hepatocyte Growth Factor Activator Inhibitor-2 Inhibits Matriptase Activity and Invasive Ability of Human Prostate Cancer Cells
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DOI: 10.1038/s41598-017-15415-4
Abstract: Dysregulation of pericellular proteolysis is often required for tumor invasion and cancer progression. It has been shown that down-regulation of hepatocyte growth factor activator inhibitor-2 (HAI-2) results in activation of matriptase (a membrane-anchored serine protease),… read more here.
Keywords: human prostate; prostate cancer; matriptase; hai ... See more keywords
PK/PD investigation of antiviral host matriptase/TMPRSS2 inhibitors in cell models
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DOI: 10.1038/s41598-024-67633-2
Abstract: Certain corona- and influenza viruses utilize type II transmembrane serine proteases for cell entry, making these enzymes potential drug targets for the treatment of viral respiratory infections. In this study, the cytotoxicity and inhibitory effects… read more here.
Keywords: host matriptase; matriptase; tmprss2 inhibitors; matriptase tmprss2 ... See more keywords
O091 Predict factors of hepatocyte growth factor family and bone morphogenetic proteins for breast cancer nodal metastasis
Sign Up to like & getrecommendations! Published in 2023 at "British Journal of Surgery"
DOI: 10.1093/bjs/znad101.091
Abstract: Lymph node metastasis is essential for the outcome of patients with breast cancer. Bone morphogenetic proteins (BMP) and hepatocyte growth factor (HGF), key to angiogenesis and metastasis of cancers, were investigated for their roles in… read more here.
Keywords: metastasis; nodal metastasis; matriptase; breast cancer ... See more keywords
SPINT2 (HAI‐2) missense variants identified in congenital sodium diarrhea/tufting enteropathy affect the ability of HAI‐2 to inhibit prostasin but not matriptase
Sign Up to like & getrecommendations! Published in 2019 at "Human Molecular Genetics"
DOI: 10.1093/hmg/ddy394
Abstract: Abstract The syndromic form of congenital sodium diarrhea (SCSD) is caused by bi‐allelic mutations in SPINT2, which encodes a Kunitz‐type serine protease inhibitor (HAI‐2). We report three novel SCSD patients, two novel SPINT2 mutations and… read more here.
Keywords: inhibit prostasin; matriptase; hai; sodium diarrhea ... See more keywords
From Dysplasia to Carcinoma: Expression Patterns of Dermokine, Matriptase, and Tryptase in OPMD.
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DOI: 10.1111/odi.70043
Abstract: BACKGROUND The malignant transformation of oral potentially malignant disorders (OPMDs) lacks reliable molecular markers. Dermokine and matriptase are involved in epithelial differentiation and inflammation, while tryptase is associated with the tumor microenvironment, which may contribute… read more here.
Keywords: dermokine matriptase; carcinoma; opmd; expression ... See more keywords
Downregulation of Matriptase Inhibits Porphyromonas gingivalis Lipopolysaccharide-Induced Matrix Metalloproteinase-1 and Proinflammatory Cytokines by Suppressing the TLR4/NF-κB Signaling Pathways in Human Gingival Fibroblasts
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DOI: 10.1155/2022/3865844
Abstract: Matriptases are cell surface proteolytic enzymes belonging to the type II transmembrane serine protease family that mediate inflammatory skin disorders and cancer progression. Matriptases may affect the development of periodontitis via protease-activated receptor-2 activity. However,… read more here.
Keywords: matriptase; downregulation; porphyromonas gingivalis; human gingival ... See more keywords
Matriptase shedding is closely coupled with matriptase zymogen activation and requires de novo proteolytic cleavage likely involving its own activity
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DOI: 10.1371/journal.pone.0183507
Abstract: The type 2 transmembrane serine protease matriptase is involved in many pathophysiological processes probably via its enzymatic activity, which depends on the dynamic relationship between zymogen activation and protease inhibition. Matriptase shedding can prolong the… read more here.
Keywords: matriptase; matriptase shedding; zymogen activation; matriptase zymogen ... See more keywords
Tissue distribution and subcellular localizations determine in vivo functional relationship among prostasin, matriptase, HAI-1, and HAI-2 in human skin
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DOI: 10.1371/journal.pone.0192632
Abstract: The membrane-bound serine proteases prostasin and matriptase and the Kunitz-type protease inhibitors HAI-1 and HAI-2 are all expressed in human skin and may form a tightly regulated proteolysis network, contributing to skin pathophysiology. Evidence from… read more here.
Keywords: human skin; skin; matriptase; hai ... See more keywords