Piperidine carbamate peptidomimetic inhibitors of the serine proteases HGFA, matriptase and hepsin.
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DOI: 10.1039/c9md00234k
Abstract: Matriptase and hepsin are type II transmembrane serine proteases (TTSPs). Along with related S1 trypsin like serine protease HGFA (hepatocyte growth factor activator), their unregulated proteolytic activity has been associated with cancer including tumor progression… read more here.
Keywords: serine proteases; piperidine carbamate; matriptase hepsin;