Mild acidity likely accelerates the physiological matriptase autoactivation process: a comparative study between spontaneous and acid-induced matriptase zymogen activation
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DOI: 10.1007/s13577-020-00410-1
Abstract: The pathophysiological functions of matriptase, a type 2 transmembrane serine protease, rely primarily on its enzymatic activity, which is under tight control through multiple mechanisms. Among those regulatory mechanisms, the control of zymogen activation is… read more here.
Keywords: acid induced; zymogen activation; matriptase; activation ... See more keywords
Matriptase shedding is closely coupled with matriptase zymogen activation and requires de novo proteolytic cleavage likely involving its own activity
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DOI: 10.1371/journal.pone.0183507
Abstract: The type 2 transmembrane serine protease matriptase is involved in many pathophysiological processes probably via its enzymatic activity, which depends on the dynamic relationship between zymogen activation and protease inhibition. Matriptase shedding can prolong the… read more here.
Keywords: matriptase; matriptase shedding; zymogen activation; matriptase zymogen ... See more keywords