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   Articles with "matrix remodeling" as a keyword



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Extracellular Matrix Remodeling Regulates Glucose Metabolism through TXNIP Destabilization

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recommendations! Published in 2018 at "Cell"

DOI: 10.1016/j.cell.2018.08.017

Abstract: The metabolic state of a cell is influenced by cell-extrinsic factors, including nutrient availability and growth factor signaling. Here, we present extracellular matrix (ECM) remodeling as another fundamental node of cell-extrinsic metabolic regulation. Unbiased analysis… read more here.

Keywords: matrix remodeling; metabolism; extracellular matrix; remodeling regulates ... See more keywords

#2290 ALOX5 regulates renal fibrosis through modulation of matrix remodeling and inflammatory responses

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recommendations! Published in 2025 at "Nephrology Dialysis Transplantation"

DOI: 10.1093/ndt/gfaf116.1339

Abstract: Renal fibrosis, a common pathological feature of Chronic Kidney Disease (CKD), exhibits excessive extracellular matrix accumulation and inflammatory cell infiltration. 5-lipoxygenase (ALOX5), a key enzyme in leukotriene B4 (LTB4) biosynthesis, plays crucial roles in inflammatory… read more here.

Keywords: fibrosis; matrix remodeling; renal fibrosis; cell ... See more keywords
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Extracellular matrix remodeling with stress and depression: Studies in human, rodent and zebrafish models

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recommendations! Published in 2020 at "European Journal of Neuroscience"

DOI: 10.1111/ejn.14910

Abstract: Emerging evidence suggests that extracellular matrix (ECM) alterations occur with stress. Specifically, increases in perineuronal net (PNN) deposition have been observed in rodents exposed to chronic corticosterone or persistent social defeat stress. The PNN is… read more here.

Keywords: matrix remodeling; extracellular matrix; stress; pnn deposition ... See more keywords

Contribution of Matrix Remodeling to Biaxial Mechanics of Right-Ventricular Myocardium in Pulmonary Arterial Hypertension.

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recommendations! Published in 2019 at "Journal of biomechanical engineering"

DOI: 10.1115/1.4044225

Abstract: Pulmonary arterial hypertension (PAH) commonly leads to right ventricular (RV) hypertrophy and fibrosis that affect the mechanical properties of the RV myocardium. To investigate the effects of PAH on the mechanics of the RV myocardium… read more here.

Keywords: matrix remodeling; arterial hypertension; right ventricular; pulmonary arterial ... See more keywords

Aged Tendons Exhibit Altered Mechanisms of Strain-dependent Extracellular Matrix Remodeling.

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recommendations! Published in 2024 at "Journal of biomechanical engineering"

DOI: 10.1115/1.4065270

Abstract: Aging is a primary risk factor for degenerative tendon injuries, yet the etiology and progression of this degeneration is poorly understood. While aged tendons have innate cellular differences that support a reduced ability to maintain… read more here.

Keywords: strain dependent; matrix remodeling; cyclic strain; aged tendons ... See more keywords

Omental Preadipocytes Stimulate Matrix Remodeling and IGF Signaling to Support Ovarian Cancer Metastasis

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recommendations! Published in 2024 at "Cancer Research"

DOI: 10.1158/0008-5472.can-23-2613

Abstract: Omental preadipocyte-mediated IGF1 signaling promotes ovarian cancer tumorigenesis and metastasis via extracellular matrix remodeling, revealing a role for preadipocytes in regulating ovarian cancer progression and highlighting potential therapeutic targets for metastatic disease. read more here.

Keywords: cancer; matrix remodeling; preadipocytes stimulate; ovarian cancer ... See more keywords

Abstract 130: Matrix remodeling promotes macrophage recruitment in breast cancer

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recommendations! Published in 2025 at "Cancer Research"

DOI: 10.1158/1538-7445.am2025-130

Abstract: A high number of tumor-associated macrophages (TAM) in breast tumors is associated with poor patient outcomes. Furthermore, activation of myosin II, a key cytoskeletal regulator, has been identified as a predictor of distant metastasis in… read more here.

Keywords: cancer; breast; matrix remodeling; macrophage recruitment ... See more keywords

Dual Contrast-Enhanced Microcomputed Tomography Uncovers Leaflet-Dependent Patterns of Macrocalcification, Fibrous Extracellular Matrix Remodeling, and Adipocyte Degeneration in Calcific Aortic Stenosis.

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recommendations! Published in 2025 at "Journal of the American Heart Association"

DOI: 10.1161/jaha.124.040616

Abstract: Background Clinical imaging studies of calcific aortic stenosis have suggested interleaflet pathological differences in patients. In this cross‐sectional study, we sought to investigate interleaflet differences in calcification, fibrous extracellular matrix remodeling, and adipocyte degeneration in… read more here.

Keywords: adipocyte degeneration; extracellular matrix; fibrous extracellular; matrix remodeling ... See more keywords

PRC2 loss drives MPNST metastasis and matrix remodeling

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recommendations! Published in 2022 at "JCI Insight"

DOI: 10.1172/jci.insight.157502

Abstract: The histone methyltransferase PRC2 plays a complex role in cancer. Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive sarcomas with frequent loss-of-function mutations in PRC2 that are associated with poor outcome. Here, we identify a… read more here.

Keywords: prc2 loss; matrix remodeling; mpnst metastasis; loss ... See more keywords

Colon stroma mediates an inflammation-driven fibroblastic response controlling matrix remodeling and healing

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recommendations! Published in 2022 at "PLoS Biology"

DOI: 10.1371/journal.pbio.3001532

Abstract: Chronic inflammation is often associated with the development of tissue fibrosis, but how mesenchymal cell responses dictate pathological fibrosis versus resolution and healing remains unclear. Defining stromal heterogeneity and identifying molecular circuits driving extracellular matrix… read more here.

Keywords: inflammation; matrix remodeling; colon stroma; remodeling healing ... See more keywords

DNA methylation and gene expression profiling reveal MFAP5 as a regulatory driver of extracellular matrix remodeling in varicose vein disease.

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recommendations! Published in 2018 at "Epigenomics"

DOI: 10.2217/epi-2018-0001

Abstract: AIM To integrate transcriptomic and DNA-methylomic measurements on varicose versus normal veins using a systems biological analysis to shed light on the interplay between genetic and epigenetic factors. MATERIALS & METHODS Differential expression and methylation… read more here.

Keywords: varicose vein; matrix remodeling; methylation; extracellular matrix ... See more keywords