Extracellular Matrix Remodeling Regulates Glucose Metabolism through TXNIP Destabilization
Sign Up to like & getrecommendations! Published in 2018 at "Cell"
DOI: 10.1016/j.cell.2018.08.017
Abstract: The metabolic state of a cell is influenced by cell-extrinsic factors, including nutrient availability and growth factor signaling. Here, we present extracellular matrix (ECM) remodeling as another fundamental node of cell-extrinsic metabolic regulation. Unbiased analysis… read more here.
Keywords: matrix remodeling; metabolism; extracellular matrix; remodeling regulates ... See more keywords
Extracellular matrix remodeling with stress and depression: Studies in human, rodent and zebrafish models
Sign Up to like & getrecommendations! Published in 2020 at "European Journal of Neuroscience"
DOI: 10.1111/ejn.14910
Abstract: Emerging evidence suggests that extracellular matrix (ECM) alterations occur with stress. Specifically, increases in perineuronal net (PNN) deposition have been observed in rodents exposed to chronic corticosterone or persistent social defeat stress. The PNN is… read more here.
Keywords: matrix remodeling; extracellular matrix; stress; pnn deposition ... See more keywords
Contribution of Matrix Remodeling to Biaxial Mechanics of Right-Ventricular Myocardium in Pulmonary Arterial Hypertension.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of biomechanical engineering"
DOI: 10.1115/1.4044225
Abstract: Pulmonary arterial hypertension (PAH) commonly leads to right ventricular (RV) hypertrophy and fibrosis that affect the mechanical properties of the RV myocardium. To investigate the effects of PAH on the mechanics of the RV myocardium… read more here.
Keywords: matrix remodeling; arterial hypertension; right ventricular; pulmonary arterial ... See more keywords
PRC2 loss drives MPNST metastasis and matrix remodeling
Sign Up to like & getrecommendations! Published in 2022 at "JCI Insight"
DOI: 10.1172/jci.insight.157502
Abstract: The histone methyltransferase PRC2 plays a complex role in cancer. Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive sarcomas with frequent loss-of-function mutations in PRC2 that are associated with poor outcome. Here, we identify a… read more here.
Keywords: prc2 loss; matrix remodeling; mpnst metastasis; loss ... See more keywords
Colon stroma mediates an inflammation-driven fibroblastic response controlling matrix remodeling and healing
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Biology"
DOI: 10.1371/journal.pbio.3001532
Abstract: Chronic inflammation is often associated with the development of tissue fibrosis, but how mesenchymal cell responses dictate pathological fibrosis versus resolution and healing remains unclear. Defining stromal heterogeneity and identifying molecular circuits driving extracellular matrix… read more here.
Keywords: inflammation; matrix remodeling; colon stroma; remodeling healing ... See more keywords
DNA methylation and gene expression profiling reveal MFAP5 as a regulatory driver of extracellular matrix remodeling in varicose vein disease.
Sign Up to like & getrecommendations! Published in 2018 at "Epigenomics"
DOI: 10.2217/epi-2018-0001
Abstract: AIM To integrate transcriptomic and DNA-methylomic measurements on varicose versus normal veins using a systems biological analysis to shed light on the interplay between genetic and epigenetic factors. MATERIALS & METHODS Differential expression and methylation… read more here.
Keywords: varicose vein; matrix remodeling; methylation; extracellular matrix ... See more keywords
Dynamic changes of enhancer and super enhancer landscape in degenerated nucleus pulposus cells
Sign Up to like & getrecommendations! Published in 2023 at "Life Science Alliance"
DOI: 10.26508/lsa.202201854
Abstract: Super-enhancers mediate inflammatory cascade and extracellular matrix remodeling in degenerated nucleus pulposus cells. Inflammatory cascade and extracellular matrix remodeling have been identified as pivotal pathological factors in the progression of intervertebral disc degeneration (IDD), but… read more here.
Keywords: extracellular matrix; inflammatory cascade; matrix remodeling; nucleus pulposus ... See more keywords
Interactive contribution of hyperinsulinemia, hyperglycemia, and mammalian target of rapamycin signaling to valvular interstitial cell differentiation and matrix remodeling
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cardiovascular Medicine"
DOI: 10.3389/fcvm.2022.942430
Abstract: Diabetes and its major key determinants insulin resistance and hyperglycemia are known risk factors for calcific aortic valve disease (CAVD). The processes leading to molecular and structural alterations of the aortic valve are yet not… read more here.
Keywords: hyperinsulinemia hyperglycemia; matrix remodeling; matrix; mtor ... See more keywords
The Role of Extracellular Matrix Remodeling in Skin Tumor Progression and Therapeutic Resistance
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2022.864302
Abstract: The extracellular matrix remodeling in the skin results from a delicate balance of synthesis and degradation of matrix components, ensuring tissue homeostasis. These processes are altered during tumor invasion and growth, generating a microenvironment that… read more here.
Keywords: matrix; extracellular matrix; matrix remodeling; tumor ... See more keywords
Evidence of Renin–Angiotensin System Receptors in Deep Fascia: A Role in Extracellular Matrix Remodeling and Fibrogenesis?
Sign Up to like & getrecommendations! Published in 2022 at "Biomedicines"
DOI: 10.3390/biomedicines10102608
Abstract: Recent studies have shown that fascial fibroblasts are sensitive to different stimuli (biochemical or biophysical), promoting extracellular matrix remodeling, as well as synthetic activity. Moreover, the extensive literature on the renin–angiotensin system (RAS) reported its… read more here.
Keywords: system; angiotensin; extracellular matrix; deep fascia ... See more keywords
Key Matrix Remodeling Enzymes: Functions and Targeting in Cancer
Sign Up to like & getrecommendations! Published in 2021 at "Cancers"
DOI: 10.3390/cancers13061441
Abstract: Simple Summary Proteolytic enzymes, such as matrix metalloproteinases, plasminogen activators and cathepsins, as well as non-proteolytic enzymatic partners, such as heparanase and hyaluron-idases, play key roles in the propagation and metastatic potential of cancer cells.… read more here.
Keywords: matrix remodeling; major matrix; remodeling enzymes; enzymes functions ... See more keywords