Tribbles 3 deficiency promotes atherosclerotic fibrous cap thickening and macrophage-mediated extracellular matrix remodelling
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DOI: 10.3389/fcvm.2022.948461
Abstract: Tribbles 3 (TRIB3) modulates lipid and glucose metabolism, macrophage lipid uptake, with a gain-of-function variant associated with increased cardiovascular risk. Here we set out to examine the role of this pseudokinase in atherosclerotic plaque development.… read more here.
Keywords: extracellular matrix; fibrous cap; matrix remodelling; trib3 ... See more keywords