Egr1 is a 3D matrix–specific mediator of mechanosensitive stem cell lineage commitment
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DOI: 10.1126/sciadv.abm4646
Abstract: While extracellular matrix (ECM) mechanics strongly regulate stem cell commitment, the field’s mechanistic understanding of this phenomenon largely derives from simplified two-dimensional (2D) culture substrates. Here, we found a 3D matrix–specific mechanoresponsive mechanism for neural… read more here.
Keywords: stem cell; egr1; lineage commitment; matrix specific ... See more keywords