Extracellular Matrix Stiffness Exists in a Feedback Loop that Drives Tumor Progression.
Sign Up to like & getrecommendations! Published in 2018 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-319-95294-9_4
Abstract: Cells communicate constantly with their surrounding extracellular matrix (ECM) to maintain homeostasis, using both mechanical and chemical signals. In cancer, abnormal signaling leads to stiffening of the ECM. A stiff microenvironment affects many aspects of… read more here.
Keywords: matrix stiffness; feedback loop; extracellular matrix; matrix ... See more keywords
Degradation rate affords a dynamic cue to regulate stem cells beyond varied matrix stiffness.
Sign Up to like & getrecommendations! Published in 2018 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2018.04.021
Abstract: While various static cues such as matrix stiffness have been known to regulate stem cell differentiation, it is unclear whether or not dynamic cues such as degradation rate along with the change of material chemistry… read more here.
Keywords: matrix stiffness; degradation; degradation rate; regulate stem ... See more keywords
Matrix stiffness regulates SMC functions via TGF-β signaling pathway.
Sign Up to like & getrecommendations! Published in 2019 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2019.119407
Abstract: The stiffness change of the vessel wall is involved in many pathological processes of the blood vessel. However, how stiffness changes regulate vascular cell phenotype is not well understood. In this study, we investigated the… read more here.
Keywords: tgf signaling; matrix stiffness; regulates smc; signaling pathway ... See more keywords
The migration of metastatic breast cancer cells is regulated by matrix stiffness via YAP signalling
Sign Up to like & getrecommendations! Published in 2021 at "Heliyon"
DOI: 10.1016/j.heliyon.2021.e06252
Abstract: Matrix stiffness is a driver of breast cancer progression and mechanosensitive transcriptional activator YAP plays an important role in this process. However, the interplay between breast cancer and matrix stiffness, and the significance of this… read more here.
Keywords: matrix stiffness; stiffness; breast cancer;
Matrix stiffness regulates the differentiation of tendon‐derived stem cells through FAK‐ERK1/2 activation
Sign Up to like & getrecommendations! Published in 2018 at "Experimental Cell Research"
DOI: 10.1016/j.yexcr.2018.08.023
Abstract: &NA; Tendon derived stem cells (TDSCs) were vital in tendon homeostasis. Nevertheless, the regulation of TDSCs differentiation in tendinopathy is unclear. Matrix stiffness modulated stem cells differentiation, and matrix stiffness of tendinopathic tissues decreased significantly.… read more here.
Keywords: matrix stiffness; stiffness; tdscs; differentiation ... See more keywords
Dynamically Modulated Core–Shell Microfibers to Study the Effect of Depth Sensing of Matrix Stiffness on Stem Cell Fate
Sign Up to like & getrecommendations! Published in 2021 at "ACS Applied Materials & Interfaces"
DOI: 10.1021/acsami.1c06752
Abstract: It is well known that extracellular matrix stiffness can affect cell fate and change dynamically during many biological processes. Existing experimental means for in situ matrix stiffness modulation often alters its structure, which could induce… read more here.
Keywords: matrix stiffness; depth sensing; cell fate; shell ... See more keywords
Matrix Stiffness Regulates GBM Migration and Chemoradiotherapy Responses via Chromatin Condensation in 3D Viscoelastic Matrices.
Sign Up to like & getrecommendations! Published in 2025 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.4c16993
Abstract: Glioblastoma multiforme (GBM) progression is associated with changes in matrix stiffness, and different regions of the tumor niche exhibit distinct stiffnesses. Using elastic hydrogels, previous work has demonstrated that matrix stiffness modulates GBM behavior and… read more here.
Keywords: gbm migration; matrix stiffness; chromatin condensation;
Mechanotransduction of matrix stiffness in regulation of focal adhesion size and number: reciprocal regulation of caveolin-1 and β1 integrin
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-14932-6
Abstract: Focal adhesion (FA) assembly, mediated by integrin activation, responds to matrix stiffness; however, the underlying mechanisms are unclear. Here, we showed that β1 integrin and caveolin-1 (Cav1) levels were decreased with declining matrix stiffness. Soft… read more here.
Keywords: matrix stiffness; focal adhesion; matrix; cav1 ... See more keywords
Matrix stiffness-dependent regulation of immunomodulatory genes in human MSCs is associated with the lncRNA CYTOR
Sign Up to like & getrecommendations! Published in 2024 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2404146121
Abstract: Significance Mechanotransduction, the translation of external physical cues to internal biochemical signals, influences cellular processes and behaviors. Here, we explore such mechanisms that underlie cellular responses to environmental stiffness using a 3D, tissue-mimetic culturing platform.… read more here.
Keywords: regulation immunomodulatory; cytor; dependent regulation; stiffness dependent ... See more keywords
Novel cryo-tomography workflow reveals nanometer-scale responses of epithelial cells to matrix stiffness and dimensionality
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Biology of the Cell"
DOI: 10.1091/mbc.e22-03-0092
Abstract: Matrix stiffness and dimensionality have been shown to be major determinants of cell behavior. However, a workflow for examining nanometer-scale responses of the associated molecular machinery is not available. Here, we describe a comprehensive, quantitative… read more here.
Keywords: stiffness dimensionality; scale responses; matrix stiffness; workflow ... See more keywords
Extracellular Matrix Stiffness Conditions Glioblastoma Cells for Long-term Migration: Mechanical Memory as a Driver of Invasion and Recurrence in Glioblastoma.
Sign Up to like & getrecommendations! Published in 2025 at "Neuro-oncology"
DOI: 10.1093/neuonc/noaf205
Abstract: Extracellular matrix (ECM) stiffening correlates with tumor invasion in various cancer types, including glioblastoma (GBM). Increased matrix stiffness promotes a migratory phenotype through dysregulation of cell-ECM bidirectional communication. Exposure to stiffer environments is sensed by… read more here.
Keywords: glioblastoma; mechanical memory; invasion; matrix stiffness ... See more keywords