IVIVC for Extended Release Hydrophilic Matrix Tablets in Consideration of Biorelevant Mechanical Stress
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DOI: 10.1007/s11095-020-02940-7
Abstract: Purpose When establishing IVIVC, a special problem arises by interpretation of averaged in vivo profiles insight of considerable individual variations in term of time and number of mechanical stress events in GI-tract. The objective of… read more here.
Keywords: mechanical stress; stress; hydrophilic matrix; dissolution ... See more keywords
Investigation of Kinetic Drug Release Characteristics and In Vitro Evaluation of Sustained-Release Matrix Tablets of a Selective COX-2 Inhibitor for Rheumatic Diseases
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DOI: 10.1007/s12247-020-09459-9
Abstract: Purpose The prevalence of rheumatic disease patients was estimated at 25% of the population. Rheumatic diseases are the leading cause of disability. The main objective of the study was to investigate the kinetic drug release… read more here.
Keywords: rheumatic diseases; formulation; drug release; matrix tablets ... See more keywords
Robustness of barrier membrane coated metoprolol tartrate matrix tablets: Drug release evaluation under physiologically relevant in vitro conditions
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DOI: 10.1016/j.ijpharm.2018.04.005
Abstract: &NA; Robust in vitro drug release behavior is an important feature of extended release (ER) hydrophilic matrix formulations for accurate prediction of in vivo drug release. In this study, ER hydrophilic matrix tablets of metoprolol… read more here.
Keywords: barrier membrane; drug release; metoprolol tartrate; matrix tablets ... See more keywords
Matrix tablets based on amino acid-derived polyesteramide containing release modifiers
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DOI: 10.1016/j.jddst.2017.05.003
Abstract: Abstract The aim of this study was to develop controlled-release matrix tablets of ketoprofen (K) and dexketoprofen trometamol (DK-T), investigating a new application of the polymer poly ( l -alanine-dodecanediol- l -alanine-sebacic) (PADAS). The influence… read more here.
Keywords: drug; drug release; matrix tablets; tablets ketoprofen ... See more keywords
The performance of HPMC matrix tablets using various agglomeration manufacturing processes
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DOI: 10.1080/03639045.2016.1249374
Abstract: Abstract Context: The flow and compaction properties of a compaction mixture or powder and the drug-release profile of final tablets are important critical quality attributes (CQAs) that have an impact on the overall performance of… read more here.
Keywords: compression; granulation; method; drug ... See more keywords
Polyethylene oxide and its controlled release properties in hydrophilic matrix tablets for oral administration
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DOI: 10.1080/10837450.2020.1808015
Abstract: Abstract Polymers are excipients that modify the rate of drug release from pharmaceutical dosage forms. Hydrophilic polymer-based controlled drug delivery system is more advantageous as compared to the conventional delivery system as it reduces the… read more here.
Keywords: polyethylene oxide; controlled release; drug; matrix tablets ... See more keywords
Zero-Order Controlled Delivery of Gliclazide from Polyethylene Oxides Matrix Tables: In vitro and In vivo Evaluation.
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DOI: 10.2174/1567201813666160322143248
Abstract: BACKGROUND In recent years, controlled and sustained release drug delivery system has become the focus of pharmaceutical researchers. Some technologies aimed to develop the controlled and sustained release of the drug, which used to be… read more here.
Keywords: system; delivery; drug; drug release ... See more keywords
APPLICATION OF NOVEL NATURAL POLYMER FOR CONTROLLING THE RELEASE OF FENOVERINE FROM CONTROLLED RELEASE MATRIX TABLETS
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DOI: 10.22159/ijap.2017v9i2.16318
Abstract: Objective: To explore a novel natural polymer, pullulan for controlling the release of fenoverine from matrix tablets and to elucidate the release kinetics of fenoverine from pullulan and HPMC matrices. Methods: In this study we… read more here.
Keywords: controlled release; polymer; drug; fenoverine ... See more keywords
FORMULATION AND IN VITRO EVALUATION OF MATRIX TABLETS OF METOCLOPRAMIDE HYDROCHLORIDE
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DOI: 10.22159/ijap.2019v11i2.30506
Abstract: Objective: The purpose of present study was to formulate oral sustained release matrix tablet of metoclopramide hydrochloride and to evaluate the effect of varying concentrations of hydrophobic and hydrophilic polymers on drug release. Methods: Drug–excipients… read more here.
Keywords: drug; metoclopramide hydrochloride; drug release; release ... See more keywords
Matrix Tablets Based on Chitosan–Carrageenan Polyelectrolyte Complex: Unique Matrices for Drug Targeting in the Intestine
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DOI: 10.3390/ph15080980
Abstract: The present study focused on the more detailed characterization of chitosan–carrageenan-based matrix tablets with respect to their potential utilization for drug targeting in the intestine. The study systematically dealt with the particular stages of the… read more here.
Keywords: chitosan carrageenan; carrageenan polyelectrolyte; targeting intestine; matrix tablets ... See more keywords
Controlled Release of Highly Hydrophilic Drugs from Novel Poly(Magnesium Acrylate) Matrix Tablets
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DOI: 10.3390/pharmaceutics12020174
Abstract: The potential of a new poly(magnesium acrylate) hydrogel (PAMgA) as a pharmaceutical excipient for the elaboration of matrix tablets for the extended release of highly hydrophilic drugs was evaluated. The polymer was synthetized with two… read more here.
Keywords: magnesium acrylate; highly hydrophilic; release highly; matrix tablets ... See more keywords