Specific MicroRNAs Found in Extracellular Matrix Vesicles Regulate Proliferation and Differentiation in Growth Plate Chondrocytes.
Sign Up to like & getrecommendations! Published in 2021 at "Calcified tissue international"
DOI: 10.1007/s00223-021-00855-y
Abstract: Matrix vesicles (MVs) are extracellular organelles produced by growth plate cartilage cells in a zone-specific manner. MVs are similar in size to exosomes, but they are tethered to the extracellular matrix (ECM) via integrins. Originally… read more here.
Keywords: plate chondrocytes; growth; matrix vesicles; growth plate ... See more keywords
Matrix vesicles induce calcification of recipient vascular smooth muscle cells through multiple signaling pathways.
Sign Up to like & getrecommendations! Published in 2018 at "Kidney international"
DOI: 10.1016/j.kint.2017.07.019
Abstract: In patients with chronic kidney and end-stage renal diseases, the major risk factor for progression of arterial calcification is the presence of existing (baseline) calcification. Here, we tested whether calcification of arteries is extended from… read more here.
Keywords: calcification recipient; vsmc; matrix vesicles; calcification ... See more keywords
Regulation of extracellular matrix vesicles via rapid responses to steroid hormones during endochondral bone formation
Sign Up to like & getrecommendations! Published in 2019 at "Steroids"
DOI: 10.1016/j.steroids.2017.12.003
Abstract: &NA; Endochondral bone formation is a precise and highly ordered process whose exact regulatory framework is still being elucidated. Multiple regulatory pathways are known to be involved. In some cases, regulation impacts gene expression, resulting… read more here.
Keywords: matrix vesicles; bone formation; extracellular matrix; matrix ... See more keywords
Matrix Vesicle–Mediated Mineralization and Potential Applications
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Dental Research"
DOI: 10.1177/00220345221103145
Abstract: Hard tissues, including the bones and teeth, are a fundamental part of the body, and their formation and homeostasis are critically regulated by matrix vesicle–mediated mineralization. Matrix vesicles have been studied for 50 y since… read more here.
Keywords: mediated mineralization; matrix vesicles; vesicle mediated; matrix vesicle ... See more keywords
From Matrix Vesicles to Miniature Rocks: Evolution of Calcium Deposits in Calf Costochondral Junctions.
Sign Up to like & getrecommendations! Published in 2020 at "Cartilage"
DOI: 10.1177/1947603520941225
Abstract: OBJECTIVE Initial stages of cartilage matrix calcification depend on the activity of matrix vesicles. The purpose of the study was to describe how calcified matrix vesicles join into larger structures, to present their up-to-date undescribed… read more here.
Keywords: matrix vesicles; costochondral junctions; microscopy; cartilage matrix ... See more keywords
Matrix Vesicles as a Therapeutic Target for Vascular Calcification
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.825622
Abstract: Vascular calcification (VC) is linked to an increased risk of heart disease, stroke, and atherosclerotic plaque rupture. It is a cell-active process regulated by vascular cells rather than pure passive calcium (Ca) deposition. In recent… read more here.
Keywords: vesicles therapeutic; matrix; therapeutic target; calcification ... See more keywords
Mineralization Profile of Annexin A6-Harbouring Proteoliposomes: Shedding Light on the Role of Annexin A6 on Matrix Vesicle-Mediated Mineralization
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23168945
Abstract: The biochemical machinery involved in matrix vesicles-mediated bone mineralization involves a specific set of lipids, enzymes, and proteins. Annexins, among their many functions, have been described as responsible for the formation and stabilization of the… read more here.
Keywords: presence; role; annexin; type collagen ... See more keywords