Progressive White Matter Injury in Preclinical Dutch Cerebral Amyloid Angiopathy
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DOI: 10.1002/ana.26429
Abstract: Autosomal‐dominant, Dutch‐type cerebral amyloid angiopathy (D‐CAA) offers a unique opportunity to develop biomarkers for pre‐symptomatic cerebral amyloid angiopathy (CAA). We hypothesized that neuroimaging measures of white matter injury would be present and progressive in D‐CAA… read more here.
Keywords: matter; amyloid angiopathy; white matter; cerebral amyloid ... See more keywords
MRI Assessment of Geometric Microstructural Changes of White Matter in Infants With Periventricular White Matter Injury and Spastic Cerebral Palsy
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Magnetic Resonance Imaging"
DOI: 10.1002/jmri.29730
Abstract: Periventricular white matter injury (PWMI) is a high‐risk factor for spastic cerebral palsy (SCP). read more here.
Keywords: white matter; cerebral palsy; matter injury; matter ... See more keywords
Umbilical cord blood cells for the treatment of preterm white matter injury: Potential effects and treatment options
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Neuroscience Research"
DOI: 10.1002/jnr.24751
Abstract: Preterm birth is a global public health problem. A large number of preterm infants survive with preterm white matter injury (PWMI), which leads to neurological deficits, and has multifaceted etiology, clinical course, monitoring, and outcomes.… read more here.
Keywords: matter injury; umbilical cord; treatment; injury ... See more keywords
White matter injury in the neonatal hypoxic‐ischemic brain and potential therapies targeting microglia
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DOI: 10.1002/jnr.24761
Abstract: Neonatal hypoxic–ischemic (H‐I) injury, which mainly causes neuronal damage and white matter injury (WMI), is among the predominant causes of infant morbidity (cerebral palsy, cognitive and persistent motor disabilities) and mortality. Disruptions to the oxygen… read more here.
Keywords: matter injury; hypoxic ischemic; brain; neonatal hypoxic ... See more keywords
White matter injury after neonatal encephalopathy is associated with thalamic metabolite perturbations
Sign Up to like & getrecommendations! Published in 2020 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2020.102663
Abstract: Background Although thalamic magnetic resonance (MR) spectroscopy (MRS) accurately predicts adverse outcomes after neonatal encephalopathy, its utility in infants without MR visible deep brain nuclei injury is not known. We examined thalamic MRS metabolite perturbations… read more here.
Keywords: matter injury; neonatal encephalopathy; adverse outcomes; metabolite perturbations ... See more keywords
The ameliorative effects of exercise on cognitive impairment and white matter injury from blood-brain barrier disruption induced by chronic cerebral hypoperfusion in adolescent rats
Sign Up to like & getrecommendations! Published in 2017 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2016.12.018
Abstract: Vascular dementia is the progressive change in blood vessels that leads to neuronal injuries in vulnerable areas induced by chronic cerebral hypoperfusion (CCH). CCH induces disruption of blood-brain barrier (BBB), and this BBB disruption can… read more here.
Keywords: matter injury; disruption; impairment white; cognitive impairment ... See more keywords
Radiographic and histologic characterisation of white matter injury in a sheep model of CHD.
Sign Up to like & getrecommendations! Published in 2022 at "Cardiology in the young"
DOI: 10.1017/s104795112200107x
Abstract: Nearly one in five children with CHD is born with white matter injury that can be recognised on postnatal MRI by the presence of T1 hyperintense lesions. This pattern of white matter injury is known… read more here.
Keywords: white matter; histologic characterisation; matter injury;
Slow rewarming after hypothermia does not ameliorate white matter injury after hypoxia-ischemia in near-term fetal sheep
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DOI: 10.1038/s41390-024-03332-y
Abstract: The optimal rate to rewarm infants after therapeutic hypothermia is unclear. In this study we examined whether slow rewarming after 72 h of hypothermia would attenuate white matter injury. Near-term fetal sheep received sham occlusion (n = 8)… read more here.
Keywords: white matter; term; hypothermia; slow rewarming ... See more keywords
Triptolide protects against white matter injury induced by chronic cerebral hypoperfusion in mice.
Sign Up to like & getrecommendations! Published in 2021 at "Acta pharmacologica Sinica"
DOI: 10.1038/s41401-021-00637-0
Abstract: White matter injury is the major pathological alteration of subcortical ischemic vascular dementia (SIVD) caused by chronic cerebral hypoperfusion. It is characterized by progressive demyelination, apoptosis of oligodendrocytes and microglial activation, which leads to impairment… read more here.
Keywords: matter injury; cerebral hypoperfusion; chronic cerebral; white matter ... See more keywords
Inhibiting miR-466b-5p Attenuates Neonatal White Matter Injury by Targeting Lpar1.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of neuropathology and experimental neurology"
DOI: 10.1093/jnen/nlac012
Abstract: miR-466b-5p is aberrantly upregulated in oligodendrocyte precursor cells (OPCs) after white matter injury (WMI). However, its roles in neonatal WMI pathogenesis are unknown. In this study, P3 rats were subjected to hypoxia-ischemia to establish a… read more here.
Keywords: white matter; inhibiting mir; mir 466b; matter injury ... See more keywords
White matter injury fuels early progression of glioblastoma.
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DOI: 10.1158/0008-5472.can-25-4362
Abstract: Glioblastoma (GBM) is the most aggressive and devastating primary brain cancer in adults. Most GBMs are diagnosed at an advanced stage with therapy resistance, posing a major obstacle to understanding the tumor microenvironment (TME) at… read more here.
Keywords: white matter; progression; glioblastoma; matter injury ... See more keywords