Progressive White Matter Injury in Preclinical Dutch Cerebral Amyloid Angiopathy
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DOI: 10.1002/ana.26429
Abstract: Autosomal‐dominant, Dutch‐type cerebral amyloid angiopathy (D‐CAA) offers a unique opportunity to develop biomarkers for pre‐symptomatic cerebral amyloid angiopathy (CAA). We hypothesized that neuroimaging measures of white matter injury would be present and progressive in D‐CAA… read more here.
Keywords: matter; amyloid angiopathy; white matter; cerebral amyloid ... See more keywords
Umbilical cord blood cells for the treatment of preterm white matter injury: Potential effects and treatment options
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Neuroscience Research"
DOI: 10.1002/jnr.24751
Abstract: Preterm birth is a global public health problem. A large number of preterm infants survive with preterm white matter injury (PWMI), which leads to neurological deficits, and has multifaceted etiology, clinical course, monitoring, and outcomes.… read more here.
Keywords: matter injury; umbilical cord; treatment; injury ... See more keywords
White matter injury in the neonatal hypoxic‐ischemic brain and potential therapies targeting microglia
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Neuroscience Research"
DOI: 10.1002/jnr.24761
Abstract: Neonatal hypoxic–ischemic (H‐I) injury, which mainly causes neuronal damage and white matter injury (WMI), is among the predominant causes of infant morbidity (cerebral palsy, cognitive and persistent motor disabilities) and mortality. Disruptions to the oxygen… read more here.
Keywords: matter injury; hypoxic ischemic; brain; neonatal hypoxic ... See more keywords
White matter injury after neonatal encephalopathy is associated with thalamic metabolite perturbations
Sign Up to like & getrecommendations! Published in 2020 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2020.102663
Abstract: Background Although thalamic magnetic resonance (MR) spectroscopy (MRS) accurately predicts adverse outcomes after neonatal encephalopathy, its utility in infants without MR visible deep brain nuclei injury is not known. We examined thalamic MRS metabolite perturbations… read more here.
Keywords: matter injury; neonatal encephalopathy; adverse outcomes; metabolite perturbations ... See more keywords
The ameliorative effects of exercise on cognitive impairment and white matter injury from blood-brain barrier disruption induced by chronic cerebral hypoperfusion in adolescent rats
Sign Up to like & getrecommendations! Published in 2017 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2016.12.018
Abstract: Vascular dementia is the progressive change in blood vessels that leads to neuronal injuries in vulnerable areas induced by chronic cerebral hypoperfusion (CCH). CCH induces disruption of blood-brain barrier (BBB), and this BBB disruption can… read more here.
Keywords: matter injury; disruption; impairment white; cognitive impairment ... See more keywords
Radiographic and histologic characterisation of white matter injury in a sheep model of CHD.
Sign Up to like & getrecommendations! Published in 2022 at "Cardiology in the young"
DOI: 10.1017/s104795112200107x
Abstract: Nearly one in five children with CHD is born with white matter injury that can be recognised on postnatal MRI by the presence of T1 hyperintense lesions. This pattern of white matter injury is known… read more here.
Keywords: white matter; histologic characterisation; matter injury;
Triptolide protects against white matter injury induced by chronic cerebral hypoperfusion in mice.
Sign Up to like & getrecommendations! Published in 2021 at "Acta pharmacologica Sinica"
DOI: 10.1038/s41401-021-00637-0
Abstract: White matter injury is the major pathological alteration of subcortical ischemic vascular dementia (SIVD) caused by chronic cerebral hypoperfusion. It is characterized by progressive demyelination, apoptosis of oligodendrocytes and microglial activation, which leads to impairment… read more here.
Keywords: matter injury; cerebral hypoperfusion; chronic cerebral; white matter ... See more keywords
Inhibiting miR-466b-5p Attenuates Neonatal White Matter Injury by Targeting Lpar1.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of neuropathology and experimental neurology"
DOI: 10.1093/jnen/nlac012
Abstract: miR-466b-5p is aberrantly upregulated in oligodendrocyte precursor cells (OPCs) after white matter injury (WMI). However, its roles in neonatal WMI pathogenesis are unknown. In this study, P3 rats were subjected to hypoxia-ischemia to establish a… read more here.
Keywords: white matter; inhibiting mir; mir 466b; matter injury ... See more keywords
Brain virtual histology with X-ray phase-contrast tomography Part I: whole-brain myelin mapping in white-matter injury models.
Sign Up to like & getrecommendations! Published in 2022 at "Biomedical optics express"
DOI: 10.1364/boe.438832
Abstract: White-matter injury leads to severe functional loss in many neurological diseases. Myelin staining on histological samples is the most common technique to investigate white-matter fibers. However, tissue processing and sectioning may affect the reliability of… read more here.
Keywords: matter injury; histology; white matter; brain ... See more keywords
Effect of the JAK2/STAT3 signaling pathway on nerve cell apoptosis in rats with white matter injury.
Sign Up to like & getrecommendations! Published in 2019 at "European review for medical and pharmacological sciences"
DOI: 10.26355/eurrev_201901_16779
Abstract: OBJECTIVE The Janus activated kinase 2 (JAK2)/signal transducer and the activator of transcription 3 (STAT3) pathway are involved in many physiological processes, such as cell survival, inflammation, development, proliferation and differentiation. Increasing evidence has shown… read more here.
Keywords: matter injury; jak2 stat3; white matter;
Effectiveness of minocycline in acute white matter injury after intracerebral hemorrhage.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of neurosurgery"
DOI: 10.3171/2016.5.jns152670
Abstract: OBJECTIVE Intracerebral hemorrhage (ICH) is a fatal disease with high morbidity and mortality, which may be followed by white matter injury (WMI) due to the local oxidizing reaction induced by iron (Fe). In this study,… read more here.
Keywords: matter injury; minocycline; intracerebral hemorrhage; injection ... See more keywords