Mutation analysis of the TUBB8 gene in nine infertile women with oocyte maturation arrest.
Sign Up to like & getrecommendations! Published in 2017 at "Reproductive biomedicine online"
DOI: 10.1016/j.rbmo.2017.05.017
Abstract: Mutations in the tubulin beta 8 class VIII (TUBB8) gene have been proven to cause oocyte maturation arrest. The aim of this study was to describe newly discovered mutations in TUBB8 and to investigate the… read more here.
Keywords: tubb8 gene; maturation arrest; women oocyte; oocyte maturation ... See more keywords
Resolvin D1 improves bleomycin-induced alveolar maturation arrest in newborn rats
Sign Up to like & getrecommendations! Published in 2025 at "Scientific Reports"
DOI: 10.1038/s41598-025-12739-4
Abstract: Sustained, non-resolving inflammation is a fundamental mechanism that causes bronchopulmonary dysplasia (BPD). Specialized pro-resolving mediators (SPMs) are attracting attention as the new endogenous anti-inflammatory agents because they facilitate only the resolution phase of inflammation without… read more here.
Keywords: rvd1; alveolar maturation; maturation arrest; bleo induced ... See more keywords
Oocyte maturation arrest produced by TUBB8 mutations: impact of genetic disorders in infertility treatment
Sign Up to like & getrecommendations! Published in 2020 at "Gynecological Endocrinology"
DOI: 10.1080/09513590.2020.1725968
Abstract: Abstract Oocyte maturation defect is a challenging situation in the management of infertility, the etiology may be related to endocrine causes, protocols used in ovarian stimulation, oocyte intrinsic defects or procedures in embryology laboratory. We… read more here.
Keywords: oocyte maturation; etiology; treatment; maturation arrest ... See more keywords
P-253 Determination of age-specific diagnostic criteria for OZEMA (Oocyte/Zygote/Embryo Maturation Arrest) phenotypes based on 16,994 cycles
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DOI: 10.1093/humrep/deaf097.561
Abstract: Can cut-off values for oocyte maturation rate (OMR), fertilization rate (FR) and blastocyst formation rate (BFR) be established to define OZEMA (Oocyte/Zygote/Embryo Maturation arrest) phenotypes? This study is the first to develop quantile regression plots… read more here.
Keywords: age; years years; cut values; maturation arrest ... See more keywords
P-594 Genetic screening in patients with oocyte/zygote/embryo maturation arrest and failed fertilization
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DOI: 10.1093/humrep/deaf097.900
Abstract: Can variant screening identify the genetic causes of female-related oocyte/zygote/embryo maturation arrest (OZEMA) and male-related failed fertilization (FF)? Genetic analysis revealed CHEK1/WEE2/TUBB8 mutations in three OZEMA/FF female patients, while PLCZ1/ACTL9/IQCN variants were found in 6… read more here.
Keywords: genetic screening; oocyte zygote; fertilization; male ... See more keywords
Pregnancy after intracytoplasmic sperm injection following extended sperm preparation and hormone therapy in an azoospermic man with maturation arrest and microlithiasis: a case report and literature review
Sign Up to like & getrecommendations! Published in 2017 at "Andrologia"
DOI: 10.1111/and.12665
Abstract: In the management of azoospermia, a combination of testicular sperm extraction and intracytoplasmic sperm injection (ICSI) is usually the most successful option for fatherhood. However, an outstanding question remains: How can at least a few… read more here.
Keywords: hormone; intracytoplasmic sperm; sperm injection; man ... See more keywords
Morphological and ultrastructural studies of human spermatogonial stem cells from patients with maturation arrest
Sign Up to like & getrecommendations! Published in 2017 at "Andrologia"
DOI: 10.1111/and.12700
Abstract: Destruction of spermatogonial stem cells (SSCs) along the chemotherapy and radiotherapy is one of the side effects of cancer treatments that lead to infertility. In vitro propagation of hSSCs is necessary to obtain an adequate… read more here.
Keywords: spermatogonial stem; stem cells; maturation arrest; patients maturation ... See more keywords
Altered gene expression profiles of testicular tissues from azoospermic patients with maturation arrest
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DOI: 10.1111/and.13812
Abstract: Maturation arrest is a common cause of male infertility which has caused worldwide concern, and its pathophysiological process remains further elucidation. Our study aimed to identify genetic characteristics of maturation arrest by comparing gene expression… read more here.
Keywords: testicular tissues; maturation; maturation arrest; gene expression ... See more keywords
Bi-allelic pathogenic variants in PABPC1L cause oocyte maturation arrest and female infertility.
Sign Up to like & getrecommendations! Published in 2023 at "EMBO molecular medicine"
DOI: 10.15252/emmm.202217177
Abstract: Oocyte maturation arrest is one of the important causes of female infertility, but the genetic factors remain largely unknown. PABPC1L, a predominant poly(A)-binding protein in Xenopus, mouse, and human oocytes and early embryos prior to… read more here.
Keywords: maturation; variants pabpc1l; maturation arrest; oocyte maturation ... See more keywords
Female infertility from oocyte maturation arrest: assembling the genetic puzzle.
Sign Up to like & getrecommendations! Published in 2023 at "EMBO molecular medicine"
DOI: 10.15252/emmm.202317729
Abstract: Assisted reproduction procedures often encounter an issue called oocyte maturation arrest (OMA), which is manifested as failed IVF/ICSI attempts using oocytes from some infertile women. In this issue of EMBO Molecular Medicine, Wang et al… read more here.
Keywords: maturation arrest; infertility oocyte; oocyte maturation; female infertility ... See more keywords