UBR5 HECT domain mutations identified in mantle cell lymphoma control maturation of B cells
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DOI: 10.1182/blood.2019002102
Abstract: Coordination of a number of molecular mechanisms including transcription, alternative splicing, and class switch recombination are required to facilitate development, activation, and survival of B cells. Disruption of these pathways can result in malignant transformation.… read more here.
Keywords: maturation; maturation cells; hect domain; mantle cell ... See more keywords