tRNA Maturation Defects Lead to Inhibition of rRNA Processing via Synthesis of pppGpp.
Sign Up to like & getrecommendations! Published in 2019 at "Molecular cell"
DOI: 10.1016/j.molcel.2019.03.030
Abstract: rRNAs and tRNAs universally require processing from longer primary transcripts to become functional for translation. Here, we describe an unsuspected link between tRNA maturation and the 3' processing of 16S rRNA, a key step in… read more here.
Keywords: maturation; maturation defects; rrna processing; trna maturation ... See more keywords
A homozygous variant in TBPL2 was identified in women with oocyte maturation defects and infertility.
Sign Up to like & getrecommendations! Published in 2021 at "Human reproduction"
DOI: 10.1093/humrep/deab094
Abstract: STUDY QUESTION What are the genetic causes of oocyte maturation defects? SUMMARY ANSWER A homozygous splicing variant (c.788 + 3A>G) in TATA-box binding protein like 2 (TBPL2) was identified as a contributory genetic factor in oocyte maturation… read more here.
Keywords: tbpl2 identified; tbpl2; maturation defects; oocyte maturation ... See more keywords
Splenectomy improves erythrocyte functionality in spherocytosis based on septin abundance but not maturation defects.
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DOI: 10.1182/bloodadvances.2022009114
Abstract: Splenectomy improves clinical parameters of patients with hereditary spherocytosis but its potential benefit to red blood cell (RBC) functionality and the mechanism behind this benefit remain largely overlooked. We here compared 7 non-splenectomized and 12… read more here.
Keywords: maturation defects; abundance; splenectomy improves; splenectomized patients ... See more keywords
Genetics of Oocyte Maturation Defects and Early Embryo Development Arrest
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DOI: 10.3390/genes13111920
Abstract: Various pathogenic factors can lead to oogenesis failure and seriously affect both female reproductive health and fertility. Genetic factors play an important role in folliculogenesis and oocyte maturation but still need to be clarified. Oocyte… read more here.
Keywords: maturation defects; maturation; arrest; genetics oocyte ... See more keywords