Heterogenous impairment of α cell function in type 2 diabetes is linked to cell maturation state.
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DOI: 10.1016/j.cmet.2021.12.021
Abstract: In diabetes, glucagon secretion from pancreatic α cells is dysregulated. The underlying mechanisms, and whether dysfunction occurs uniformly among cells, remain unclear. We examined α cells from human donors and mice using electrophysiological, transcriptomic, and… read more here.
Keywords: type diabetes; cell maturation; maturation state; cell ... See more keywords