Essential requirement for polypyrimidine tract binding proteins 1 and 3 in the maturation and maintenance of mature B cells in mice
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DOI: 10.1002/eji.202149257
Abstract: The maturation of immature B cells and the survival of mature B cells is stringently controlled to maintain a diverse repertoire of antibody specificities while avoiding selfâreactivity. At the molecular level this is regulated by… read more here.
Keywords: mature cells; binding proteins; ptbp1 ptbp3; polypyrimidine tract ... See more keywords
NK cell recovery after haploidentical HSCT with posttransplant cyclophosphamide: dynamics and clinical implications.
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DOI: 10.1182/blood-2017-05-780668
Abstract: The use of posttransplant cyclophosphamide (PT-Cy) as graft-versus-host disease (GVHD) prophylaxis has revolutionized haploidentical hematopoietic stem cell transplantation (HSCT), allowing safe infusion of unmanipulated T cell-replete grafts. PT-Cy selectively eliminates proliferating alloreactive T cells, but… read more here.
Keywords: mature cells; posttransplant cyclophosphamide; cell recovery; hsct ... See more keywords
Contribution of mutant HSC clones to immature and mature cells in MDS and CMML, and variations with AZA therapy.
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DOI: 10.1182/blood.2022018602
Abstract: Myelodysplastic Neoplasms (MDS) and Chronic Myelomonocytic Leukemia (CMML) are clonal disorders driven by progressively acquired somatic mutations in hematopoietic stem cells (HSCs). Hypomethylating agents (HMA) can modify the clinical course of MDS and CMML. Clinical… read more here.
Keywords: immature mature; mature cells; progenitor; mds cmml ... See more keywords
Proapoptotic BIM Impacts B Lymphoid Homeostasis by Limiting the Survival of Mature B Cells in a Cell-Autonomous Manner
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DOI: 10.3389/fimmu.2018.00592
Abstract: The proapoptotic BH3-only protein BIM (Bcl2l11) plays key roles in the maintenance of multiple hematopoietic cell types. In mice, germline knockout or conditional pan-hematopoietic deletion of Bim results in marked splenomegaly and significantly increased numbers… read more here.
Keywords: mature; mature cells; deletion; cell ... See more keywords