Structures of plasmepsin X from Plasmodium falciparum reveal a novel inactivation mechanism of the zymogen and molecular basis for binding of inhibitors in mature enzyme
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DOI: 10.1002/pro.4279
Abstract: Plasmodium falciparum plasmepsin X (PfPMX), involved in the invasion and egress of this deadliest malarial parasite, is essential for its survival and hence considered as an important drug target. We report the first crystal structure… read more here.
Keywords: zymogen; pfpmx; mature enzyme; plasmodium falciparum ... See more keywords