The novel synthetic microneurotrophin BNN27 protects mature oligodendrocytes against cuprizone‐induced death, through the NGF receptor TrkA
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DOI: 10.1002/glia.23170
Abstract: BNN27, a member of a chemical library of C17‐spiroepoxy derivatives of the neurosteroid DHEA, has been shown to regulate neuronal survival through its selective interaction with NGF receptors (TrkA and p75NTR), but its role on… read more here.
Keywords: cuprizone; novel synthetic; mature oligodendrocytes; ngf ... See more keywords
Regional and age‐related diversity of human mature oligodendrocytes
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DOI: 10.1002/glia.24230
Abstract: Morphological and emerging molecular studies have provided evidence for heterogeneity within the oligodendrocyte population. To address the regional and age‐related heterogeneity of human mature oligodendrocytes (MOLs) we applied single‐cell RNA sequencing to cells isolated from… read more here.
Keywords: human mature; age related; regional age; age ... See more keywords
High-efficiency brain-targeted intranasal delivery of BDNF mediated by engineered exosomes to promote remyelination.
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DOI: 10.1039/d2bm00518b
Abstract: The regeneration of myelin sheaths is the ultimate goal of the treatment of demyelination disease, including multiple sclerosis (MS). However, current drugs for MS mainly target the immune system and can only slow down the… read more here.
Keywords: remyelination; brain targeted; brain; bdnf ... See more keywords
Neuroprotective effects of ellagic acid on cuprizone-induced acute demyelination through limitation of microgliosis, adjustment of CXCL12/IL-17/IL-11 axis and restriction of mature oligodendrocytes apoptosis
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DOI: 10.1080/13880209.2017.1319867
Abstract: Abstract Context: Ellagic acid (EA) is a natural phenol antioxidant with various therapeutic activities. However, the efficacy of EA has not been examined in neuropathologic conditions. Objective: In vivo neuroprotective effects of EA on cuprizone… read more here.
Keywords: mature; demyelination; neuroprotective effects; mature oligodendrocytes ... See more keywords
A detrimental role of RelB in mature oligodendrocytes during experimental acute encephalomyelitis
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DOI: 10.1186/s12974-019-1548-7
Abstract: BackgroundMultiple sclerosis (MS) is an autoimmune demyelinating disease of the central nervous system (CNS). It is firmly established that overactivation of the p65 (RelA) nuclear factor kappa B (NF-κB) transcription factor upregulates expression of inflammatory… read more here.
Keywords: inflammation; cns; relb; role relb ... See more keywords