A clinical mutation in glucokinase causing maturity-onset diabetes in the young type 2 increases enzyme activity.
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DOI: 10.1002/1873-3468.14561
Abstract: Glucokinase (GCK) is the pancreatic β-cell glucose sensor, and its kinetics are key to that purpose. A slow transition step, displayed as non-hyperbolic kinetics, and a low affinity for glucose characterize GCK. Mutations in GCK… read more here.
Keywords: young type; diabetes young; maturity onset; onset diabetes ... See more keywords
Diabetic Hepatosclerosis in a Woman with Maturity-Onset Diabetes of the Young Type 3
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DOI: 10.1007/s10620-021-07005-2
Abstract: Diabetic hepatosclerosis (DHS), initially described in 2006, represents a form of diabetic microangiopathy of the liver found in patients with long-standing diabetes mellitus with other microvascular complications [1]. DHS is characterized by hepatic sinusoidal fibrosis… read more here.
Keywords: diabetes young; young type; onset diabetes; maturity onset ... See more keywords
Maturity Onset Diabetes of the Young is Not Necessarily Associated with Autosomal Inheritance: Case Description of a De Novo HFN1A Mutation
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DOI: 10.1007/s13300-019-0633-3
Abstract: Maturity onset diabetes of the young (MODY) accounts for up to 4% of all cases of diabetes in pediatric patients. MODY is usually characterized by autosomal dominant inheritance, impaired insulin secretion, and an average age… read more here.
Keywords: diabetes young; onset diabetes; maturity onset; case ... See more keywords
Ocular surface assessment in maturity-onset diabetes of the young
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DOI: 10.1007/s13410-020-00843-2
Abstract: Aim To examine ocular surface changes in patients with maturity-onset diabetes of young (MODY). Material and methods Fifty patients with MODY who were transferred to Genetic Diagnosis Department of Diskapi Yildirim Beyazit Training and Research… read more here.
Keywords: ocular surface; diabetes young; onset diabetes; maturity onset ... See more keywords
A case of a novel mutation in HNF1β-related maturity-onset diabetes of the young type 5 with diabetic kidney disease complication in a Chinese family.
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DOI: 10.1016/j.jdiacomp.2016.11.011
Abstract: AIMS Precise diagnosis of maturity-onset diabetes of the young (MODY) has proven valuable for understanding mechanism of diabetes and selecting optimal therapy. A proband and her mother with diabetic kidney disease (DKD) were studied to… read more here.
Keywords: diabetes young; onset diabetes; maturity onset; family ... See more keywords
Maturity‐Onset Diabetes of the Young: A Genetic Form of Diabetes in Children☆
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DOI: 10.1016/j.pedn.2016.11.003
Abstract: Clinical Features That Raise Suspicion for MODY. Type 1 (T1) and type 2 (T2) diabetes mellitus (DM) are the most commonly recognized disease states characterized by hyperglycemia. However, diabetes compromises many disorders with hyperglycemia as… read more here.
Keywords: diabetes young; young genetic; onset diabetes; maturity onset ... See more keywords
Prevalence of maturity-onset diabetes of the young in phenotypic type 2 diabetes in young adults: a nationwide, multi-center, cross-sectional survey in China
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DOI: 10.1097/cm9.0000000000002321
Abstract: Abstract Background: Maturity-onset diabetes of the young (MODY) is the most common monogenic diabetes. The aim of this study was to assess the prevalence of MODY in phenotypic type 2 diabetes (T2DM) among Chinese young… read more here.
Keywords: diabetes young; prevalence; mody; maturity onset ... See more keywords
How do I diagnose Maturity Onset Diabetes of the Young (MODY) in my patients?
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DOI: 10.1111/cen.14744
Abstract: Maturity Onset diabetes of the Young (MODY) is a monogenic form of diabetes diagnosed in young individuals that lack the typical features of type 1 and type 2 diabetes. The genetic subtype of MODY determines… read more here.
Keywords: young mody; onset diabetes; diabetes young; maturity onset ... See more keywords
Maturity‐onset diabetes of the young type 5 uncovered during pregnancy with a long‐term diagnosis of type 1 diabetes
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DOI: 10.1111/jdi.13036
Abstract: We report a case of missed diagnosis of maturity‐onset diabetes of the young type 5 uncovered during pregnancy with a previous diagnosis of type 1 diabetes. Maturity‐onset diabetes of the young type 5 cannot be… read more here.
Keywords: young type; diabetes young; onset diabetes; maturity onset ... See more keywords
Pregnancy outcome of Japanese patients with glucokinase–maturity‐onset diabetes of the young
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DOI: 10.1111/jdi.13046
Abstract: Glucokinase–maturity‐onset diabetes of the young (GCK‐MODY; also known as MODY2) is a benign hyperglycemic condition, which generally does not require medical interventions. The only known exception is increased birthweight and related perinatal complications in unaffected… read more here.
Keywords: pregnancy; diabetes young; onset diabetes; maturity onset ... See more keywords
Targeted gene panel analysis of Japanese patients with maturity‐onset diabetes of the young‐like diabetes mellitus: Roles of inactivating variants in the ABCC8 and insulin resistance genes
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DOI: 10.1111/jdi.13957
Abstract: To investigate the genetic background of Japanese patients with suspected maturity‐onset diabetes of the young (MODY). read more here.
Keywords: diabetes young; maturity onset; onset diabetes; japanese patients ... See more keywords