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   Articles with "mavs" as a keyword



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Mitochondrial morphology and MAVS‐IFN1 signaling pathway in muscles of anti‐MDA5 dermatomyositis

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recommendations! Published in 2021 at "Annals of Clinical and Translational Neurology"

DOI: 10.1002/acn3.51311

Abstract: This study aimed to investigate mitochondrial changes and the mitochondrial antiviral‐signaling protein (MAVS)‐type I interferon (IFN1) signaling pathway in the muscles of anti‐melanoma differentiation gene 5(MDA5) dermatomyositis (DM) patients. read more here.

Keywords: pathway muscles; muscles anti; ifn1 signaling; mda5 dermatomyositis ... See more keywords

The Endoplasmic Reticulum ATP13A1 is Essential for MAVS‐Mediated Antiviral Innate Immunity

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recommendations! Published in 2022 at "Advanced Science"

DOI: 10.1002/advs.202203831

Abstract: RIG‐I‐MAVS signaling pathway is essential for efficient innate immune response against virus infection. Though many components have been identified in RIG‐I pathway and it can be partially reconstituted in vitro, detailed mechanisms involved in cells… read more here.

Keywords: endoplasmic reticulum; antiviral innate; mediated antiviral; mavs ... See more keywords
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Methods to Visualize MAVS Subcellular Localization.

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recommendations! Published in 2017 at "Methods in molecular biology"

DOI: 10.1007/978-1-4939-7237-1_7

Abstract: The mitochondrial antiviral signaling (MAVS) protein is a central adaptor protein required for antiviral innate immune signaling. To facilitate its roles in innate immunity, MAVS localizes to multiple intracellular membranous compartments, including the mitochondria, the… read more here.

Keywords: mavs subcellular; visualize mavs; mavs; subcellular localization ... See more keywords

Detection and Quantification of MAVS Aggregation via Confocal Microscopy.

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recommendations! Published in 2018 at "Methods in molecular biology"

DOI: 10.1007/978-1-4939-7519-8_16

Abstract: During infection, the cytosolic detection of viral double-stranded RNA (dsRNA) leads to the oligomerization and activation of mitochondrial antiviral signaling protein (MAVS) and the subsequent production of type I interferon (IFN). Here, we describe a… read more here.

Keywords: detection quantification; aggregation; microscopy; mavs ... See more keywords

Apoptotic Caspases Suppress Type I Interferon Production via the Cleavage of cGAS, MAVS, and IRF3.

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recommendations! Published in 2019 at "Molecular cell"

DOI: 10.1016/j.molcel.2019.02.013

Abstract: Viral infection triggers host defenses through pattern-recognition receptor-mediated cytokine production, inflammasome activation, and apoptosis of the infected cells. Inflammasome-activated caspases are known to cleave cyclic GMP-AMP synthase (cGAS). Here, we found that apoptotic caspases are… read more here.

Keywords: mavs irf3; cleavage; infection; mavs ... See more keywords

Residues Asn118 and Glu119 of hepatitis B virus X protein are critical for HBx-mediated inhibition of RIG-I-MAVS signaling.

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recommendations! Published in 2019 at "Virology"

DOI: 10.1016/j.virol.2019.10.009

Abstract: Hepatitis B virus (HBV) X protein (HBx) has been reported to counteract the innate immune responses through interfering with the pattern recognition receptors signaling activated by retinoic acid-inducible gene-I (RIG-I)-mitochondrial antiviral signaling protein (MAVS). Here,… read more here.

Keywords: hbx; hepatitis virus; rig mavs; mavs ... See more keywords

Novel insights into stress-induced susceptibility to influenza: corticosterone impacts interferon-β responses by Mfn2-mediated ubiquitin degradation of MAVS

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recommendations! Published in 2020 at "Signal Transduction and Targeted Therapy"

DOI: 10.1038/s41392-020-00238-z

Abstract: Although stress has been known to increase the susceptibility of pathogen infection, the underlying mechanism remains elusive. In this study, we reported that restraint stress dramatically enhanced the morbidity and mortality of mice infected with… read more here.

Keywords: corticosterone; susceptibility; mavs; stress ... See more keywords
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USP18 positively regulates innate antiviral immunity by promoting K63-linked polyubiquitination of MAVS

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recommendations! Published in 2021 at "Nature Communications"

DOI: 10.1038/s41467-021-23219-4

Abstract: Activation of MAVS, an adaptor molecule in Rig-I-like receptor (RLR) signaling, is indispensable for antiviral immunity, yet the molecular mechanisms modulating MAVS activation are not completely understood. Ubiquitination has a central function in regulating the… read more here.

Keywords: antiviral immunity; linked polyubiquitination; k63 linked; mavs ... See more keywords

Targeting PRMT7-mediated monomethylation of MAVS enhances antiviral innate immune responses and inhibits RNA virus replication

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recommendations! Published in 2024 at "Proceedings of the National Academy of Sciences of the United States of America"

DOI: 10.1073/pnas.2408117121

Abstract: Significance The outbreak of viral infectious diseases has posed a serious threat to public health security in recent years, and therefore effective antiviral strategies are urgently needed. RIG-I-like receptors (RLRs)/mitochondrial antiviral signaling (MAVS)-induced type I… read more here.

Keywords: mavs; rna virus; innate immune; immune responses ... See more keywords

Suppression of innate immune signaling molecule, MAVS, reduces radiation-induced bystander effect

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recommendations! Published in 2020 at "International Journal of Radiation Biology"

DOI: 10.1080/09553002.2020.1807642

Abstract: Abstract Purpose Mitochondrial antiviral signaling (MAVS) protein, located in the mitochondrial out-membrane, is necessary for IFN-beta induction and IFN-stimulated gene expression in response to external stress such as viral invasion and ionizing radiation (IR). Although… read more here.

Keywords: ribe; recipient cells; radiation induced; mavs ... See more keywords

Aggregatin is a mitochondrial regulator of MAVS activation to drive innate immunity.

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recommendations! Published in 2025 at "Journal of immunology"

DOI: 10.1093/jimmun/vkae019

Abstract: Mitochondrial antiviral-signaling protein (MAVS) is a key adapter protein required for inducing type I interferons (IFN-Is) and other antiviral effector molecules. The formation of MAVS aggregates on mitochondria is essential for its activation; however, the… read more here.

Keywords: mavs; innate immunity; aggregation; activation ... See more keywords