Mitochondrial morphology and MAVS‐IFN1 signaling pathway in muscles of anti‐MDA5 dermatomyositis
Sign Up to like & getrecommendations! Published in 2021 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.51311
Abstract: This study aimed to investigate mitochondrial changes and the mitochondrial antiviral‐signaling protein (MAVS)‐type I interferon (IFN1) signaling pathway in the muscles of anti‐melanoma differentiation gene 5(MDA5) dermatomyositis (DM) patients. read more here.
Keywords: pathway muscles; muscles anti; ifn1 signaling; mda5 dermatomyositis ... See more keywords
The Endoplasmic Reticulum ATP13A1 is Essential for MAVS‐Mediated Antiviral Innate Immunity
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202203831
Abstract: RIG‐I‐MAVS signaling pathway is essential for efficient innate immune response against virus infection. Though many components have been identified in RIG‐I pathway and it can be partially reconstituted in vitro, detailed mechanisms involved in cells… read more here.
Keywords: endoplasmic reticulum; antiviral innate; mediated antiviral; mavs ... See more keywords
Methods to Visualize MAVS Subcellular Localization.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7237-1_7
Abstract: The mitochondrial antiviral signaling (MAVS) protein is a central adaptor protein required for antiviral innate immune signaling. To facilitate its roles in innate immunity, MAVS localizes to multiple intracellular membranous compartments, including the mitochondria, the… read more here.
Keywords: mavs subcellular; visualize mavs; mavs; subcellular localization ... See more keywords
Detection and Quantification of MAVS Aggregation via Confocal Microscopy.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7519-8_16
Abstract: During infection, the cytosolic detection of viral double-stranded RNA (dsRNA) leads to the oligomerization and activation of mitochondrial antiviral signaling protein (MAVS) and the subsequent production of type I interferon (IFN). Here, we describe a… read more here.
Keywords: detection quantification; aggregation; microscopy; mavs ... See more keywords
Apoptotic Caspases Suppress Type I Interferon Production via the Cleavage of cGAS, MAVS, and IRF3.
Sign Up to like & getrecommendations! Published in 2019 at "Molecular cell"
DOI: 10.1016/j.molcel.2019.02.013
Abstract: Viral infection triggers host defenses through pattern-recognition receptor-mediated cytokine production, inflammasome activation, and apoptosis of the infected cells. Inflammasome-activated caspases are known to cleave cyclic GMP-AMP synthase (cGAS). Here, we found that apoptotic caspases are… read more here.
Keywords: mavs irf3; cleavage; infection; mavs ... See more keywords
Residues Asn118 and Glu119 of hepatitis B virus X protein are critical for HBx-mediated inhibition of RIG-I-MAVS signaling.
Sign Up to like & getrecommendations! Published in 2019 at "Virology"
DOI: 10.1016/j.virol.2019.10.009
Abstract: Hepatitis B virus (HBV) X protein (HBx) has been reported to counteract the innate immune responses through interfering with the pattern recognition receptors signaling activated by retinoic acid-inducible gene-I (RIG-I)-mitochondrial antiviral signaling protein (MAVS). Here,… read more here.
Keywords: hbx; hepatitis virus; rig mavs; mavs ... See more keywords
Novel insights into stress-induced susceptibility to influenza: corticosterone impacts interferon-β responses by Mfn2-mediated ubiquitin degradation of MAVS
Sign Up to like & getrecommendations! Published in 2020 at "Signal Transduction and Targeted Therapy"
DOI: 10.1038/s41392-020-00238-z
Abstract: Although stress has been known to increase the susceptibility of pathogen infection, the underlying mechanism remains elusive. In this study, we reported that restraint stress dramatically enhanced the morbidity and mortality of mice infected with… read more here.
Keywords: corticosterone; susceptibility; mavs; stress ... See more keywords
USP18 positively regulates innate antiviral immunity by promoting K63-linked polyubiquitination of MAVS
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-23219-4
Abstract: Activation of MAVS, an adaptor molecule in Rig-I-like receptor (RLR) signaling, is indispensable for antiviral immunity, yet the molecular mechanisms modulating MAVS activation are not completely understood. Ubiquitination has a central function in regulating the… read more here.
Keywords: antiviral immunity; linked polyubiquitination; k63 linked; mavs ... See more keywords
Suppression of innate immune signaling molecule, MAVS, reduces radiation-induced bystander effect
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DOI: 10.1080/09553002.2020.1807642
Abstract: Abstract Purpose Mitochondrial antiviral signaling (MAVS) protein, located in the mitochondrial out-membrane, is necessary for IFN-beta induction and IFN-stimulated gene expression in response to external stress such as viral invasion and ionizing radiation (IR). Although… read more here.
Keywords: ribe; recipient cells; radiation induced; mavs ... See more keywords
The Human Papillomavirus E6 Oncoprotein Targets USP15 and TRIM25 To Suppress RIG-I-Mediated Innate Immune Signaling
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Virology"
DOI: 10.1128/jvi.01737-17
Abstract: ABSTRACT Retinoic acid-inducible gene I (RIG-I) is a key pattern recognition receptor that senses viral RNA and interacts with the mitochondrial adaptor MAVS, triggering a signaling cascade that results in the production of type I… read more here.
Keywords: rig; trim25; mavs; rig mediated ... See more keywords
SARS-CoV-2 Nsp5 Demonstrates Two Distinct Mechanisms Targeting RIG-I and MAVS To Evade the Innate Immune Response
Sign Up to like & getrecommendations! Published in 2021 at "mBio"
DOI: 10.1128/mbio.02335-21
Abstract: The ongoing COVID-19 pandemic is caused by SARS-CoV-2, which is rapidly evolving with better transmissibility. Understanding the molecular basis of the SARS-CoV-2 interaction with host cells is of paramount significance, and development of antiviral agents… read more here.
Keywords: innate immune; cov nsp5; mavs; sars cov ... See more keywords