Activation of GPR75 Signaling Pathway Contributes to the Effect of a 20-HETE Mimetic, 5,14-HEDGE, to Prevent Hypotensive and Tachycardic Responses to Lipopolysaccharide in a Rat Model of Septic Shock
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DOI: 10.1097/fjc.0000000000001265
Abstract: Supplemental Digital Content is Available in the Text. Abstract The orphan receptor, G protein–coupled receptor (GPR) 75, which has been shown to mediate various effects of 20-hydroxyeicosatetraenoic acid (20-HETE), is considered as a therapeutic target… read more here.
Keywords: gpr75 signaling; git1; maxik; hete mimetic ... See more keywords
Urothelial MaxiK-activity regulates mucosal and detrusor metabolism
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DOI: 10.1371/journal.pone.0189387
Abstract: There is increasing evidence for a role of MaxiK potassium channel-activity in regulating the metabolism and intracellular signaling of non-contractile bladder mucosal tissues. At present however no studies have determined the impact of urothelial MaxiK-activity… read more here.
Keywords: maxik; detrusor; metabolism; mucosal ... See more keywords