Caffeine impairs anticonvulsant effects of levetiracetam in the maximal electroshock seizure threshold test in mice
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Basic and Clinical Physiology and Pharmacology"
DOI: 10.1515/jbcpp-2022-0224
Abstract: Abstract Objectives Caffeine is the most widely used psychoactive substance in the world. Animal studies indicate that acute caffeine exposure at high doses may induce seizures and diminish the anticonvulsant activity of antiepileptic drugs (AEDs)… read more here.
Keywords: seizure threshold; lev; caffeine; electroshock seizure ... See more keywords
Insulin potentiates the anticonvulsive activity of phenytoin against maximal electroshock-induced seizures in mice.
Sign Up to like & getrecommendations! Published in 2022 at "European review for medical and pharmacological sciences"
DOI: 10.26355/eurrev_202211_30389
Abstract: INTRODUCTION The limitations imposed by the blood-brain barrier (BBB) on the sufficient accumulation of antiepileptic drugs (AEDs) in the epileptogenic focus is considered the major cause of the high percentage of morbidity and mortality cases… read more here.
Keywords: electroshock; electroshock induced; activity; pht ... See more keywords
Interaction of Varenicline with Classic Antiseizure Medications in the Mouse Maximal Electroshock-Induced Seizure Model
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24032616
Abstract: Varenicline (VAR) is a partial agonist of brain α4β2 nicotinic acetylcholine receptors recommended as a first line pharmacotherapy for smoking cessation. The aim of this study was to examine whether VAR affects the protective activity… read more here.
Keywords: antiseizure medications; protective activity; var; classic antiseizure ... See more keywords