Modeling near-continuous clinical endpoint as categorical: application to longitudinal exposure–response modeling of Mayo scores for golimumab in patients with ulcerative colitis
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DOI: 10.1007/s10928-018-9610-0
Abstract: Accurate characterization of exposure–response relationship of clinical endpoints is important in drug development to identify optimal dose regimens. Endpoints with ≥ 10 ordered categories are typically analyzed as continuous. This manuscript aims to show circumstances where… read more here.
Keywords: mayo scores; modeling mayo; response modeling; exposure response ... See more keywords